. 2016 Oct;45(5):1619-1630.

doi: 10.1093/ije/dyw207. Epub 2016 Sep 4.

Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study

Jue-Sheng Ong^{1

2}, Gabriel Cuellar-Partida^{1

2}, Yi Lu¹; Australian Ovarian Cancer Study; Peter A Fasching^{3

4}, Alexander Hein⁴, Stefanie Burghaus⁴, Matthias W Beckmann⁴, Diether Lambrechts^{5

6}, Els Van Nieuwenhuysen⁷, Ignace Vergote⁷, Adriaan Vanderstichele⁷, Jennifer Anne Doherty^{1

2}, Mary Anne Rossing^{8

9}, Jenny Chang-Claude¹⁰, Ursula Eilber¹⁰, Anja Rudolph¹⁰, Shan Wang-Gohrke¹¹, Marc T Goodman^{12

13}, Natalia Bogdanova¹⁴, Thilo Dörk¹⁵, Matthias Dürst¹⁶, Peter Hillemanns¹⁷, Ingo B Runnebaum¹⁶, Natalia Antonenkova¹⁸, Ralf Butzow¹⁹, Arto Leminen²⁰, Heli Nevanlinna²⁰, Liisa M Pelttari²⁰, Robert P Edwards^{21

22}, Joseph L Kelley²¹, Francesmary Modugno, Kirsten B Moysich²³, Roberta B Ness²⁴, Rikki Cannioto²³, Estrid Høgdall^{25

26}, Claus K Høgdall²⁷, Allan Jensen²⁵, Graham G Giles, Fiona Bruinsma²⁸, Susanne K Kjaer^{25

27}, Michelle At Hildebrandt²⁹, Dong Liang³⁰, Karen H Lu³¹, Xifeng Wu²⁹, Maria Bisogna³², Fanny Dao³², Douglas A Levine³², Daniel W Cramer³³, Kathryn L Terry³³, Shelley S Tworoger^{34

35}, Meir Stampfer^{34

35}, Stacey Missmer, Line Bjorge^{36

37}, Helga B Salvesen^{36

37}, Reidun K Kopperud^{36

37}, Katharina Bischof^{36

37}, Katja Kh Aben^{38

39}, Lambertus A Kiemeney³⁸, Leon Fag Massuger⁴⁰, Angela Brooks-Wilson^{41

42}, Sara H Olson⁴³, Valerie McGuire⁴⁴, Joseph H Rothstein⁴⁴, Weiva Sieh⁴⁴, Alice S Whittemore⁴⁴, Linda S Cook⁴⁵, Nhu D Le⁴⁶, C Blake Gilks⁴⁷, Jacek Gronwald⁴⁸, Anna Jakubowska⁴⁸, Jan Lubiński⁴⁸, Tomasz Kluz⁴⁹, Honglin Song⁵⁰, Jonathan P Tyrer⁵⁰, Nicolas Wentzensen⁵¹, Louise Brinton⁵¹, Britton Trabert⁵¹, Jolanta Lissowska⁵², John R McLaughlin⁵³, Steven A Narod⁵⁴, Catherine Phelan⁵⁵, Hoda Anton-Culver^{56

57}, Argyrios Ziogas⁵⁶, Diana Eccles⁵⁸, Ian Campbell⁵⁹, Simon A Gayther⁶⁰, Aleksandra Gentry-Maharaj⁶¹, Usha Menon⁶¹, Susan J Ramus⁶⁰, Anna H Wu⁶⁰, Agnieszka Dansonka-Mieszkowska⁶², Jolanta Kupryjanczyk⁶³, Agnieszka Timorek⁶³, Lukasz Szafron⁶², Julie M Cunningham⁶⁴, Brooke L Fridley⁶⁵, Stacey J Winham⁶⁶, Elisa V Bandera⁶⁷, Elizabeth M Poole^{34

35}, Terry K Morgan⁶⁸, Harvey A Risch⁶⁹, Ellen L Goode⁷⁰, Joellen M Schildkraut^{71

72}, Celeste L Pearce^{60

73}, Andrew Berchuck⁷⁴, Paul Dp Pharoah^{75

50}, Georgia Chenevix-Trench⁷⁶, Puya Gharahkhani¹, Rachel E Neale^{77

78}, Penelope M Webb⁷⁷, Stuart MacGregor⁷⁹

Affiliations

¹ Statistical Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
² School of Medicine, University of Queensland, St Lucia, QLD 4072, Australia.
³ Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles.
⁴ University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
⁵ Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium.
⁶ Vesalius Research Center, VIB, Leuven, Belgium.
⁷ Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
⁸ Department of Epidemiology, University of Washington, Seattle, WA, USA.
⁹ Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
¹⁰ German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany.
¹¹ Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
¹² Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
¹³ Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
¹⁴ Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany.
¹⁵ Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
¹⁶ Department of Gynecology, Jena-University Hospital-Friedrich Schiller University, Jena, Germany.
¹⁷ Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
¹⁸ N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus.
¹⁹ Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
²⁰ Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
²¹ Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
²² Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
²³ Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
²⁴ The University of Texas School of Public Health, Houston, TX, USA.
²⁵ Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
²⁶ Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
²⁷ Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
²⁸ Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
²⁹ Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³⁰ College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA.
³¹ Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³² Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
³³ Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA.
³⁴ Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
³⁵ Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
³⁶ Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
³⁷ Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
³⁸ Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands.
³⁹ Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.
⁴⁰ Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Obstetrics and Gynaecology, Nijmegen, The Netherlands.
⁴¹ Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.
⁴² Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
⁴³ Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY, USA.
⁴⁴ Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
⁴⁵ Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
⁴⁶ Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.
⁴⁷ Pathology and Laboratory Medicine, University of British Columbia, Vancouver BC, Canada.
⁴⁸ International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
⁴⁹ Institute of Midwifery and Emergency Medicine, Clinic of Obstetrics and Gynecology, Frederick Chopin Clinical Provincial Hospital No 1, Faculty of Medicine, University of Rzeszów, Poland.
⁵⁰ The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
⁵¹ Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
⁵² Department of Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland.
⁵³ Public Health Ontario, Toronto, ON, Canada.
⁵⁴ Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
⁵⁵ Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
⁵⁶ Department of Epidemiology, University of California Irvine, Irvine, CA, USA.
⁵⁷ Center for Cancer Genetics Research & Prevention, School of Medicine, University of California Irvine, Irvine, CA, USA.
⁵⁸ Faculty of Medicine, University of Southampton, Southampton, UK.
⁵⁹ Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia.
⁶⁰ Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
⁶¹ Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom.
⁶² Department of Pathology and Laboratory Diagnostics, the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
⁶³ Department of Obstetrics, Gynaecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland.
⁶⁴ Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA.
⁶⁵ Department of Biostatistics, University of Kansas, Kansas City, KS, USA.
⁶⁶ Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
⁶⁷ Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
⁶⁸ Departments of Pathology and Obstetrics & Gynaecology, OHSU, Portland, OR, USA.
⁶⁹ Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
⁷⁰ Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
⁷¹ Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA.
⁷² Cancer Control and Population Sciences, Duke Cancer Institute, Durham, NC, USA.
⁷³ Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
⁷⁴ Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA and.
⁷⁵ The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
⁷⁶ Cancer Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
⁷⁷ Gynaecological Cancers laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
⁷⁸ Cancer Aetiology and Prevention laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
⁷⁹ Statistical Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia, stuart.macgregor@www.qiuluzeuv.cn.

PMID: 27594614
PMCID: VSports - PMC5100621
DOI: 10.1093/ije/dyw207

VSports在线直播 - Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study

Jue-Sheng Ong et al. Int J Epidemiol. 2016 Oct.

. 2016 Oct;45(5):1619-1630.

doi: 10.1093/ije/dyw207. Epub 2016 Sep 4.

Authors (V体育官网)

Affiliations

¹ Statistical Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
² School of Medicine, University of Queensland, St Lucia, QLD 4072, Australia.
³ Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles.
⁴ University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
⁵ Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium.
⁶ Vesalius Research Center, VIB, Leuven, Belgium.
⁷ Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
⁸ Department of Epidemiology, University of Washington, Seattle, WA, USA.
⁹ Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
¹⁰ German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany.
¹¹ Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
¹² Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
¹³ Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
¹⁴ Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany.
¹⁵ Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
¹⁶ Department of Gynecology, Jena-University Hospital-Friedrich Schiller University, Jena, Germany.
¹⁷ Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
¹⁸ N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus.
¹⁹ Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
²⁰ Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
²¹ Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
²² Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
²³ Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
²⁴ The University of Texas School of Public Health, Houston, TX, USA.
²⁵ Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
²⁶ Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
²⁷ Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
²⁸ Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
²⁹ Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³⁰ College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA.
³¹ Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³² Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
³³ Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA.
³⁴ Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
³⁵ Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
³⁶ Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
³⁷ Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
³⁸ Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands.
³⁹ Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.
⁴⁰ Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Obstetrics and Gynaecology, Nijmegen, The Netherlands.
⁴¹ Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.
⁴² Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
⁴³ Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY, USA.
⁴⁴ Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
⁴⁵ Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
⁴⁶ Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.
⁴⁷ Pathology and Laboratory Medicine, University of British Columbia, Vancouver BC, Canada.
⁴⁸ International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
⁴⁹ Institute of Midwifery and Emergency Medicine, Clinic of Obstetrics and Gynecology, Frederick Chopin Clinical Provincial Hospital No 1, Faculty of Medicine, University of Rzeszów, Poland.
⁵⁰ The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
⁵¹ Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
⁵² Department of Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland.
⁵³ Public Health Ontario, Toronto, ON, Canada.
⁵⁴ Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
⁵⁵ Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
⁵⁶ Department of Epidemiology, University of California Irvine, Irvine, CA, USA.
⁵⁷ Center for Cancer Genetics Research & Prevention, School of Medicine, University of California Irvine, Irvine, CA, USA.
⁵⁸ Faculty of Medicine, University of Southampton, Southampton, UK.
⁵⁹ Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia.
⁶⁰ Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
⁶¹ Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom.
⁶² Department of Pathology and Laboratory Diagnostics, the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
⁶³ Department of Obstetrics, Gynaecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland.
⁶⁴ Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA.
⁶⁵ Department of Biostatistics, University of Kansas, Kansas City, KS, USA.
⁶⁶ Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
⁶⁷ Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
⁶⁸ Departments of Pathology and Obstetrics & Gynaecology, OHSU, Portland, OR, USA.
⁶⁹ Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
⁷⁰ Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
⁷¹ Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA.
⁷² Cancer Control and Population Sciences, Duke Cancer Institute, Durham, NC, USA.
⁷³ Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
⁷⁴ Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA and.
⁷⁵ The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
⁷⁶ Cancer Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
⁷⁷ Gynaecological Cancers laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
⁷⁸ Cancer Aetiology and Prevention laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
⁷⁹ Statistical Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia, stuart.macgregor@www.qiuluzeuv.cn.

PMID: 27594614
PMCID: "VSports app下载" PMC5100621
DOI: 10.1093/ije/dyw207

"V体育2025版" Abstract

Background: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention VSports手机版. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potential limitation of observational studies is inadequate control of confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate the association between single nucleotide polymorphisms (SNPs) associated with circulating 25-hydroxyvitamin D [25(OH)D] concentration and risk of ovarian cancer. .

Methods: We employed SNPs with well-established associations with 25(OH)D concentration as instrumental variables for MR: rs7944926 (DHCR7), rs12794714 (CYP2R1) and rs2282679 (GC). We included 31 719 women of European ancestry (10 065 cases, 21 654 controls) from the Ovarian Cancer Association Consortium, who were genotyped using customized Illumina Infinium iSelect (iCOGS) arrays. A two-sample (summary data) MR approach was used and analyses were performed separately for all ovarian cancer (10 065 cases) and for high-grade serous ovarian cancer (4121 cases). V体育安卓版.

Results: The odds ratio for epithelial ovarian cancer risk (10 065 cases) estimated by combining the individual SNP associations using inverse variance weighting was 1. 27 (95% confidence interval: 1. 06 to 1. 51) per 20 nmol/L decrease in 25(OH)D concentration. The estimated odds ratio for high-grade serous epithelial ovarian cancer (4121 cases) was 1. 54 (1. 19, 2. 01) V体育ios版. .

Conclusions: Genetically lowered 25-hydroxyvitamin D concentrations were associated with higher ovarian cancer susceptibility in Europeans. These findings suggest that increasing plasma vitamin D levels may reduce risk of ovarian cancer. VSports最新版本.

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Figures

**Figure 1.**
Schematic of the Mendelian randomization framework in our study using vitamin D SNPs as instrumental variables.

**Figure 2.**
Causal OR of 25(OH)D on all ovarian cancer and high grade serous ovarian cancer.

**Figure 3.**
Causal OR of 25(OH)D on individual ovarian cancer subtypes.

See this image and copyright information in PMC

Comment in (V体育2025版)

Commentary: Mendelian randomization analysis identifies circulating vitamin D as a causal risk factor for ovarian cancer.
Bull CJ, Yarmolinsky J, Wade KH. Bull CJ, et al. Int J Epidemiol. 2016 Oct;45(5):1631-1633. doi: 10.1093/ije/dyw265. Int J Epidemiol. 2016. PMID: 27892412 Free PMC article. No abstract available.

References (VSports)

1. Sung PL, Chang YH, Chao KC, Chuang CM, Task Force on Systematic R, Meta-analysis of Ovarian C. Global distribution pattern of histological subtypes of epithelial ovarian cancer: a database analysis and systematic review. Gynecol Oncol 2014;133(2):147–54. - VSports手机版 - PubMed
1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011;61(2):69–90. - PubMed
1. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136(5):E359–86. - PubMed
1. Lu Y, Cuellar-Partida G, Painter JN, et al. Shared genetics underlying epidemiological association between endometriosis and ovarian cancer. Hum Mol Genet 2015;24(20):5955–64. - PMC - PubMed
1. Salehi F, Dunfield L, Phillips KP, Krewski D, Vanderhyden BC. Risk factors for ovarian cancer: an overview with emphasis on hormonal factors. J Toxicol Environ Health B Crit Rev 2008;11(3–4):301–21. - PubMed

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Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study

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VSports在线直播 - Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study

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