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. 2016 Jul;12(1):3-10.
doi: 10.3892/ol.2016.4609. Epub 2016 May 18.

Oncogenic role of the Notch pathway in primary liver cancer

Jie Lu  1 , Yujing Xia  1 , Kan Chen  1 , Yuanyuan Zheng  1 , Jianrong Wang  2 , Wenxia Lu  2 , Qin Yin  3 , Fan Wang  1 , Yingqun Zhou  1 , Chuanyong Guo  1
Affiliations

Oncogenic role of the Notch pathway in primary liver cancer

Jie Lu et al. Oncol Lett. 2016 Jul.

Erratum in

Abstract (VSports手机版)

Primary liver cancer, which includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, is one of the most common malignancies and the third leading cause of cancer-associated mortality, worldwide. Despite the development of novel therapies, the prognosis of liver cancer patients remains extremely poor. Thus, investigation of the genetic background and molecular mechanisms underlying the development and progression of this disease has gained significant attention VSports手机版. The Notch signaling pathway is a crucial determinant of cell fate during development and disease in several organs. In the liver, Notch signaling is involved in biliary tree development and tubulogenesis, and is also significant in the development of HCC and ICC. These findings suggest that the modulation of Notch pathway activity may have therapeutic relevance. The present review summarizes Notch signaling during HCC and ICC development and discusses the findings of recent studies regarding Notch expression, which reveal novel insights into its function in liver cancer progression. .

Keywords: Notch signaling pathway; cancer stem cells; hepatocellular carcinoma; intrahepatic cholangiocarcinoma. V体育安卓版.

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Figures

Figure 1.
Figure 1.
Model of the Notch pathway in major signaling cascades, including signal initiation through binding of the Notch ligand, cleavage of Notch, nuclear translation and transcriptional activation. NICD, notch intracellular domain; RBPJ, signal binding protein for immunoglobulin Kappa J region.
Figure 2.
Figure 2.
Schematic of the RBPJ structure and domains demonstrating the domain organization of RBPJ, NICD and MAM. The transcriptionally active RBPJ-NICD-MAM ternary complex binds to DNA. MAM is red and DNA is green. NTD, N-terminal domain; BTD, β-trefoil domain; CTD, C-terminal domain; RAM, RBPJ-associated module; ANK, ankyrin; MAM, Mastermind; RBPJ, signal binding protein for immunoglobulin Kappa J region; NICD, notch intracellular domain.
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