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Review
. 2016 Aug:41:25-32.
doi: 10.1016/j.ceb.2016.03.012. Epub 2016 Apr 7.

"V体育2025版" Lipid unsaturation and organelle dynamics

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Review

Lipid unsaturation and organelle dynamics

Hélène Barelli et al. Curr Opin Cell Biol. 2016 Aug.

Abstract

The number of double bonds (=unsaturation) in the acyl chains of phospholipids (PL) influences the physical properties of cellular membranes. Here, we discuss disparate molecular processes, including vesicle budding, ion channel opening, and lipoprotein formation, which are greatly facilitated by PL polyunsaturation in membranes VSports手机版. Experimental and computer-based approaches for the structure and dynamics of PL suggest a common cause for these effects: the ability of the polyunsaturated acyl chain of PL to extend or bent along the membrane normal according to various constraints, thereby enabling a third dimension of motion in a structure that is essentially a 2D fluid. .

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