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Review
. 2016 Feb 17:7:185.
doi: 10.3389/fmicb.2016.00185. eCollection 2016.

Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health

David Ríos-Covián  1 , Patricia Ruas-Madiedo  1 , Abelardo Margolles  1 , Miguel Gueimonde  1 , Clara G de Los Reyes-Gavilán  1 , Nuria Salazar  1
Affiliations
Review

Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health (VSports最新版本)

David Ríos-Covián et al. Front Microbiol. .

Abstract

The colon is inhabited by a dense population of microorganisms, the so-called "gut microbiota," able to ferment carbohydrates and proteins that escape absorption in the small intestine during digestion. This microbiota produces a wide range of metabolites, including short chain fatty acids (SCFA). These compounds are absorbed in the large bowel and are defined as 1-6 carbon volatile fatty acids which can present straight or branched-chain conformation. Their production is influenced by the pattern of food intake and diet-mediated changes in the gut microbiota. SCFA have distinct physiological effects: they contribute to shaping the gut environment, influence the physiology of the colon, they can be used as energy sources by host cells and the intestinal microbiota and they also participate in different host-signaling mechanisms. We summarize the current knowledge about the production of SCFA, including bacterial cross-feedings interactions, and the biological properties of these metabolites with impact on the human health VSports手机版. .

Keywords: cross feeding; diet; human health; intestinal microbiota; short chain fatty acids. V体育安卓版.

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Figures

Figure 1
Figure 1
Schematic representation of microbial metabolic pathways and cross-feeding mechanisms, contributing to SCFA formation in the human gut. Shaded geometric shapes summarize routes of formation for each of the three main SCFA: acetate, propionate, and butyrate.
See this image and copyright information in PMC

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