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. 2016 Jan 28:9:23-31.
doi: 10.2147/IBPC.S96092. eCollection 2016.

"V体育官网入口" Chronic resveratrol reverses a mild angiotensin II-induced pressor effect in a rat model

Kevin L Gordish  1 , William H Beierwaltes  2
Affiliations

Chronic resveratrol reverses a mild angiotensin II-induced pressor effect in a rat model

Kevin L Gordish et al. Integr Blood Press Control. .

Abstract

Resveratrol is reported to reduce blood pressure in animal models of hypertension, but the mechanisms are unknown VSports手机版. We have shown that resveratrol infusion increases sodium excretion. We hypothesized that chronic ingestion of resveratrol would reduce angiotensin II (Ang II)-induced increases in blood pressure by decreasing oxidative stress and by also decreasing sodium reabsorption through a nitric oxide-dependent mechanism. We infused rats with vehicle or 80 μg Ang II/d over 4 weeks. Vehicle or Ang II-infused rats were individually housed, pair fed, and placed on a diet of normal chow or normal chow plus 146 mg resveratrol/d. Groups included 1) control, 2) resveratrol-fed, 3) Ang II-treated, and 4) Ang II plus resveratrol. Systolic blood pressure was measured by tail cuff. During the 4th week, rats were placed in metabolic caging for urine collection. NO2/NO3 and 8-isoprostane excretion were measured. Ang II increased systolic blood pressure in the 1st week by +14±5 mmHg (P<0. 05) in Group 3 and +10±3 mmHg (P<0. 05) in Group 4, respectively. Blood pressure was unchanged in Groups 1 and 2. After 4 weeks, blood pressure remained elevated in Group 3 rats with Ang II (+9±3 mmHg, P<0. 05), but in Group 4, blood pressure was no longer elevated (+2±2 mmHg). We found no significant differences between the groups in sodium excretion or cumulative sodium balance (18. 49±0. 12, 17. 75±0. 16, 17. 97±0. 17, 18. 46±0. 18 μEq Na+/7 d in Groups 1-4, respectively). Urinary excretion of NO2/NO3 in the four groups was 1) 1631±207 μmol/24 h, 2) 1045±236 μmol/24 h, 3) 1490±161 μmol/24 h, and 4) 609±17 μmol/24 h. 8-Isoprostane excretion was 1) 63. 85±19. 39 nmol/24 h, 2) 73. 57±22. 02 nmol/24 h, 3) 100. 69±37. 62 nmol/24 h, and 4) 103. 00±38. 88 nmol/24 h. We conclude that chronic resveratrol supplementation does not blunt Ang II-increased blood pressure, and while resveratrol has mild depressor effects, these do not seem to be due to natriuresis or enhanced renal nitric oxide synthesis. .

Keywords: angiotensin; natriuresis; resveratrol; sodium balance; sodium excretion. V体育安卓版.

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Figures

Figure 1
Figure 1
The change in systolic blood pressure over 4 weeks. Notes: Systolic blood pressure remained unchanged in the control and resveratrol-treated groups (Groups 1 and 2). Blood pressure initially increased with Ang II infusion (Groups 3 and 4), but between weeks 3 and 4, the increase in systolic blood pressure was reversed in the Ang II plus resveratrol group (Group 4). *P<0.05 versus week 0 control. Abbreviations: Ang II, angiotensin II; Resv, resveratrol.
Figure 2
Figure 2
The change in body weight measured over 4 weeks. Notes: Body weight in all four groups significantly increased over 4 weeks (P<0.05), but no differences in growth were seen between the four groups. Abbreviations: Ang II, angiotensin II; Resv, resveratrol.
Figure 3
Figure 3
Mean 24-hour urinary sodium excretion measured over the final 7 days of the protocol. Notes: There were no differences in sodium excretion between the four groups. Abbreviations: Ang II, angiotensin II; Resv, resveratrol.
Figure 4
Figure 4
Cumulative sodium balance measured over the final 7 days of the protocol. Notes: There were no differences in cumulative sodium balance between the four groups. Abbreviation: Ang II, angiotensin II.
Figure 5
Figure 5
Clearance of creatinine: there were no differences in clearance of creatinine between the four groups. Abbreviations: Ang II, angiotensin II; Resv, resveratrol.
Figure 6
Figure 6
Urinary excretion of NO2/NO3. Notes: Resveratrol did not increase excretion of nitric oxide metabolites. NO2/NO3 excretion was decreased in Ang II plus resveratrol group. Abbreviations: Ang II, angiotensin II; Resv, resveratrol.
Figure 7
Figure 7
Urinary excretion of 8-isoprostane. Notes: Resveratrol did not decrease renal oxidative stress, as no differences were observed between groups in urinary excretion of 8-isoprostane. Abbreviations: Ang II, angiotensin II; Resv, resveratrol.
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