Objective: Peroxisome proliferator activated receptor γ-activating drugs show various salutary effects in preclinical models of neurodegenerative disease VSports手机版. The decade-long clinical usage of these drugs as antidiabetics now allows for evaluation of patient-oriented data sources. .

Methods: Using observational data from 2004-2010, we analyzed the association of pioglitazone and incidence of dementia in a prospective cohort study of 145,928 subjects aged ≥60 years who, at baseline, were free of dementia and insulin-dependent diabetes mellitus V体育安卓版. We distinguished between nondiabetics, diabetics without pioglitazone, diabetics with prescriptions of <8 calendar quarters of pioglitazone, and diabetics with ≥8 quarters. Cox proportional hazard models explored the relative risk (RR) of dementia incidence dependent on pioglitazone use adjusted for sex, age, use of rosiglitazone or metformin, and cardiovascular comorbidities. .

Results: Long-term use of pioglitazone was associated with a lower dementia incidence V体育ios版. Relative to nondiabetics, the cumulative long-term use of pioglitazone reduced the dementia risk by 47% (RR = 0. 53, p = 0. 029). If diabetes patients used pioglitazone <8 quarters, the dementia risk was comparable to those of nondiabetics (RR = 1. 16, p = 0. 317), and diabetes patients without a pioglitazone treatment had a 23% increase in dementia risk (RR = 1. 23, p < 0. 001). We did not find evidence for age effects, nor for selection into pioglitazone treatment due to obesity. .

Interpretation: These findings indicate that pioglitazone treatment is associated with a reduced dementia risk in initially non-insulin-dependent diabetes mellitus patients. Prospective clinical trials are needed to evaluate a possible neuroprotective effect in these patients in an ageing population VSports最新版本. .