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. 2014 Aug 3;3(8):e953423.
doi: 10.4161/21624011.2014.953423. eCollection 2014.

Innate γδT17 cells convert cancer-elicited inflammation into immunosuppression through myeloid-derived suppressor cells

Jun Yan  1 , Jian Huang  2
Affiliations

Innate γδT17 cells convert cancer-elicited inflammation into immunosuppression through myeloid-derived suppressor cells

Jun Yan et al. Oncoimmunology. .

Abstract

Chronic inflammation has been linked to cancer development and metastasis VSports手机版. We have recently demonstrated that γδ T cells are the major cellular source of IL-17 (γδT17) and accumulation of γδT17 cells correlates with human colorectal cancer progression through recruitment and expansion of myeloid-derived suppressor cells, thus converting tumor-elicited inflammation into immunosuppression. .

Keywords: APC, antigen-presenting cell; CRC, colorectal cancer; DAMP, danger-associated molecular pattern; DC, dendritic cell; GM-CSF; IL-17; KO, knock out; MDSC, myeloid-derived suppressor cell; MMP, matrix metalloproteinase; PGE2, prostaglandin E2; PMN, polymorphonuclear; VEGF, vascular endothelial growth factor; granulocyte-macrophage colony-stimulating factor; inflammation; myeloid-derived suppressor cells; tumor progression; γδ T cells V体育安卓版. .

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Figures

Figure 1.
Figure 1.
Innate γδT17 cells convert cancer-elicited inflammation into immunosuppression through MDSCs. Activation and expansion of γδT17 cells in the tumor, stimulates the recruitment and accumulation of MDSCs leading to immunosuppression and tumor progression. DAMP, danger-associated molecular pattern; MDSC, myeloid-derived suppressor cell; DC, dendritic cell.
See this image and copyright information in PMC

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