Objective: Depression in people with epilepsy (PWE) is underdiagnosed and undertreated VSports手机版. The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a screening questionnaire used for detecting major depressive episode (MDE) in PWE, and is already validated in 10 languages. However a version in French, one of the world's widely spoken languages, was, until now, lacking. We aimed to translate and validate the French NDDI-E. .

Methods: This study was performed under the auspices of the ILAE. People with epilepsy >18years of age were recruited from 2 specialist epilepsy units in Marseille, France. Two native French speakers and 2 native English speakers performed a forward-backward translation. The Mini International Neuropsychiatric Interview (MINI) was performed as the gold standard, and the Center for Epidemiological Studies Depression symptoms index (CES-D) was performed for external validity. Data were compared between PWE with MDE and PWE without MDE using the chi-square test and Student's t-test. Internal structural validity, external validity, and receiver operator characteristics were analyzed V体育安卓版. .

Results: Testing was performed on 116 PWE: mean age=40. 39years (SD=13. 83, range: [18-81]years old); 58. 6% (68) were women; 87. 1% had focal epilepsy. Using the MINI, we found that 33 (28. 4%) patients had current MDE and that 15 (12. 9%) patients had dysthymia; also, we found that 37 (31. 9%) patients presented suicidal ideation and/or behavior. Cronbach's alpha coefficient was 0. 838, indicating satisfactory internal consistency. Correlation between the NDDI-E and the CES-D scores was high (r(116)=0. 817, p<0. 0001), indicating good external validity. Receiver operator characteristic analysis showed an area under the curve of 0. 958 (95% CI=0. 904-0. 986), (p<0. 0001), indicating good capacity of the NDDI-E to detect MDE (defined by MINI). The cutoff for maximal sensitivity and specificity was 15. The mean NDDI-E score in PWE with MDE was 18. 27 (SD=2. 28), and the mean NDDI-E score in PWE without MDE was 10. 61 (SD=3 V体育ios版. 63). .

Significance: This study validated the French NDDI-E, with a cutoff score of 15/24 for MDE, similar to previous studies, and reinforces the NDDI-E as a global tool for detection of MDE VSports最新版本. .