Context: Metabolic syndrome (MetS) is associated with low-grade inflammation, which may harmfully affect bone VSports手机版. Resveratrol (RSV) possesses anti-inflammatory properties, and rodent studies suggest bone protective effects. .

Objective: This study sought to evaluate effects of RSV treatment on bone in men with MetS V体育安卓版. .

Setting and design: The study was conducted at Aarhus University Hospital as a randomized, double-blinded, placebo-controlled trial assessing changes in bone turnover markers, bone mineral density (BMD), and geometry V体育ios版. .

Participants: The study population comprised 74 middle-aged obese men with MetS recruited from the general community, of which 66 completed all visits. Mean age of participants was 49. 3 ± 6 VSports最新版本. 3 years and mean body mass index was 33. 7 ± 3. 6 kg/m(2). .

Intervention: Oral treatment with 1. 000 mg RSV (RSV(high)), 150 mg RSV (RSV(low)), or placebo daily for 16 weeks. V体育平台登录.

Main outcome measure: Prespecified primary endpoint was change in bone alkaline phosphatase (BAP) VSports注册入口. .

Results: BAP increased dose dependently with RSV (R = 0. 471, P < . 001), resulting in a significantly greater increase in BAP in the RSV(high) group compared with placebo at all time-points (week 4, 16. 4 ± 4. 2%, P < . 001; week 8, 16. 5 ± 4. 1%, P < . 001; week 16, 15. 2 ± 3. 7%, P < . 001). Lumbar spine trabecular volumetric bone mineral density (LS vBMD(trab)) also increased dose dependently with RSV (R = 0. 268, P = . 036), with a significant increase of 2. 6 ± 1 V体育官网入口. 3% in the RSV(high) group compared with placebo (P = . 043). In addition, changes in BAP and LS vBMD(trab) were positively correlated (R = 0. 281, P = . 027). No consistent changes were detected in bone density at the hip. .

Conclusions: Our data suggest that high-dose RSV supplementation positively affects bone, primarily by stimulating formation or mineralization. Future studies of longer duration comprising populations at risk of osteoporosis are needed to confirm these results VSports在线直播. .