Objective: According to the recent theories on the ovarian cancer origin, any protective effect of tubal ligation may vary with histologic subtype of ovarian cancer VSports手机版. Furthermore, bilateral salpingectomy may represent an opportunity for surgical prevention of serous ovarian cancer. .

Design: Nationwide register-based case-control study V体育安卓版. .

Setting: Denmark during 1982-2011 V体育ios版. .

Population: Cases were all Danish women diagnosed with epithelial ovarian cancer (n = 13 241) or borderline ovarian tumor (n = 3605) in the study period VSports最新版本. Age-matched female population controls were randomly selected by risk set sampling. We required that cases and controls have no previous cancer and that controls have no previous bilateral oophorectomy. .

Methods: Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals, adjusting for potential confounders. V体育平台登录.

Main outcome measures: Epithelial ovarian cancer and borderline ovarian tumors stratified according to histology. VSports注册入口.

Results: Tubal ligation reduced overall epithelial ovarian cancer risk (odds ratios 0. 87; 95% confidence interval 0. 78-0. 98). We observed significant risk variation according to histology (p = 0 V体育官网入口. 003) with the strongest risk reductions associated with endometrioid cancer (odds ratios 0. 66; 95% confidence interval 0. 47-0. 93) and epithelial ovarian cancer of "other" histology (odds ratios 0. 60; 95% confidence interval 0. 43-0. 83). Tubal ligation was not associated with risk of borderline ovarian tumors. Finally, bilateral salpingectomy reduced epithelial ovarian cancer risk by 42% (odds ratios 0. 58; 95% confidence interval 0. 36-0. 95). .

Conclusions: We confirmed that tubal ligation reduces the risk of epithelial ovarian cancer and particularly endometrioid cancer. To our knowledge, this is the first observational publication to report on salpingectomy and ovarian cancer risk and our promising findings warrant further investigation. VSports在线直播.