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Meta-Analysis
. 2014 Jul 22;64(3):281-9.
doi: 10.1016/j.jacc.2014.03.048.

Alcohol consumption and risk of atrial fibrillation: a prospective study and dose-response meta-analysis (V体育官网)

Susanna C Larsson  1 , Nikola Drca  2 , Alicja Wolk  3
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Free article
Meta-Analysis

Alcohol consumption and risk of atrial fibrillation: a prospective study and dose-response meta-analysis

Susanna C Larsson et al. J Am Coll Cardiol. .
Free article

Abstract

Background: Although high alcohol consumption has been associated with increased risk of atrial fibrillation (AF), the role of light to moderate drinking remains unclear VSports手机版. .

Objectives: The study sought to investigate the association between alcohol consumption and AF risk in a prospective study of Swedish men and women and to conduct a meta-analysis of prospective studies to summarize available evidence. V体育安卓版.

Methods: We followed 79,019 men and women who, at baseline, were free from AF and had completed a questionnaire about alcohol consumption and other risk factors for chronic diseases. Incident AF cases were ascertained by linkage to the Swedish Inpatient Register V体育ios版. For the meta-analysis, studies were identified by searching PubMed through January 10, 2014, and by reviewing references of pertinent publications. Study-specific relative risks (RRs) were combined using a random effects model. .

Results: Over 859,420 person-years of follow-up (1998 to 2009), 7,245 incident AF cases were identified in our own cohort study. The association between alcohol consumption and AF did not differ by sex (p for interaction = 0. 74). Compared with current drinkers of <1 drink/week (12 g alcohol/drink), the multivariable RRs of AF were 1. 01 (95% confidence interval [CI]: 0 VSports最新版本. 94 to 1. 09) for 1 to 6 drinks/week, 1. 07 (95% CI: 0. 98 to 1. 17) for 7 to 14 drinks/week, 1. 14 (95% CI: 1. 01 to 1. 28) for 15 to 21 drinks/week, and 1. 39 (95% CI: 1. 22 to 1. 58) for >21 drinks/week. Results were similar after excluding binge drinkers. In a meta-analysis of 7 prospective studies, including 12,554 AF cases, the RRs were 1. 08 (95% CI: 1. 06 to 1. 10) for 1 drink/day, 1. 17 (95% CI: 1. 13 to 1. 21) for 2 drinks/day, 1. 26 (95% CI: 1. 19 to 1. 33) for 3 drinks/day, 1. 36 (95% CI: 1. 27 to 1. 46) for 4 drinks/day, and 1. 47 (95% CI: 1. 34 to 1. 61) for 5 drinks/day, compared with nondrinkers. .

Conclusions: These findings indicate that alcohol consumption, even at moderate intakes, is a risk factor for atrial fibrillation. V体育平台登录.

Keywords: alcohol; atrial fibrillation; meta-analysis; prospective studies; risk factors VSports注册入口. .

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