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Comparative Study
. 2014 Jul 2;62(26):6147-58.
doi: 10.1021/jf500639f. Epub 2014 Jun 13.

Bioactive compounds from culinary herbs inhibit a molecular target for type 2 diabetes management, dipeptidyl peptidase IV (V体育ios版)

Allyson M Bower  1 , Luis M Real Hernandez, Mark A Berhow, Elvira Gonzalez de Mejia
Affiliations
Comparative Study

Bioactive compounds from culinary herbs inhibit a molecular target for type 2 diabetes management, dipeptidyl peptidase IV

Allyson M Bower et al. J Agric Food Chem. .

Abstract

Greek oregano (Origanum vulgare), marjoram (Origanum majorana), rosemary (Rosmarinus officinalis), and Mexican oregano (Lippia graveolens) are concentrated sources of bioactive compounds. The aims were to characterize and examine extracts from greenhouse-grown or commercially purchased herbs for their ability to inhibit dipeptidyl peptidase IV (DPP-IV) and protein tyrosine phosphatase 1B (PTP1B), enzymes that play a role in insulin secretion and insulin signaling, respectively. Greenhouse herbs contained more polyphenols (302. 7-430. 1 μg of gallic acid equivalents/mg of dry weight of extract (DWE)) and flavonoids (370. 1-661. 4 μg of rutin equivalents/mg of DWE) compared to the equivalent commercial herbs. Greenhouse rosemary, Mexican oregano, and marjoram extracts were the best inhibitors of DPP-IV (IC₅₀=16, 29, and 59 μM, respectively). Commercial rosemary, Mexican oregano, and marjoram were the best inhibitors of PTP1B (32. 4-40. 9% at 500 μM). The phytochemicals eriodictyol, naringenin, hispidulin, cirsimaritin, and carnosol were identified by LC-ESI-MS as being present in greenhouse-grown Mexican oregano and rosemary VSports手机版. Computational modeling indicated that hispidulin, carnosol, and eriodictyol would have the best binding affinities for DPP-IV. Biochemically, the best inhibitors of DPP-IV were cirsimaritin (IC₅₀=0. 43±0. 07 μM), hispidulin (IC₅₀=0. 49±0. 06 μM), and naringenin (IC₅₀=2. 5±0. 29 μM). Overall, herbs contain several flavonoids that inhibit DPP-IV and should be investigated further regarding their potential in diabetes management. .

Keywords: DPP-IV; PTP1B; hispidulin; marjoram; oregano; rosemary; type 2 diabetes mellitus V体育安卓版. .

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