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Review
. 2014 Jul;16(7):446.
doi: 10.1007/s11906-014-0446-8.

Cardiac target organ damage in hypertension: insights from epidemiology

Patrick R Lawler  1 , Pranoti Hiremath, Susan Cheng
Affiliations
Review

Cardiac target organ damage in hypertension: insights from epidemiology

"VSports" Patrick R Lawler et al. Curr Hypertens Rep. 2014 Jul.

Abstract

Hypertension is an important risk factor implicated in the development of multiple common cardiac conditions, including coronary atherosclerosis, heart failure, and atrial fibrillation. Epidemiologic studies have provided insights into the shared pathogenesis of hypertension and subclinical as well as clinically evident cardiac diseases VSports手机版. The mechanistic common ground between chronic blood pressure elevation and cardiac disease likely begins early in life. Understanding these connections will aid ongoing efforts to identify individuals at risk, develop targeted therapeutics, and improve overall outcomes for individuals with elevated blood pressure in the population at large. .

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Figures

Figure 1
Figure 1. Pathogenesis of hypertensive cardiac disease
The pathogenesis of hypertension and several common cardiac conditions share genetic, biologic, and clinical determinants. Independently, and through hypertension, these common risk factors are associated with the initial development of subclinical alterations in cardiac structure and function as well as the eventual development of overt clinical cardiac disease. To illustrate this concept, examples are highlighted for three outcomes: atrial fibrillation (green), heart failure with preserved ejection fraction (red), and atherosclerotic coronary artery disease (purple). Note that these examples are only illustrative and not exhaustive, as the spectrum of mechanistic common ground is broad and multifactorial.
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