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Review
. 2014 Feb 10:7:8.
doi: 10.3389/fnmol.2014.00008. eCollection 2014.

Early-life stress impacts the developing hippocampus and primes seizure occurrence: cellular, molecular, and epigenetic mechanisms

Li-Tung Huang  1
Affiliations
Review

V体育安卓版 - Early-life stress impacts the developing hippocampus and primes seizure occurrence: cellular, molecular, and epigenetic mechanisms

V体育官网 - Li-Tung Huang. Front Mol Neurosci. .

"VSports在线直播" Abstract

Early-life stress includes prenatal, postnatal, and adolescence stress. Early-life stress can affect the development of the hypothalamic-pituitary-adrenal (HPA) axis, and cause cellular and molecular changes in the developing hippocampus that can result in neurobehavioral changes later in life. Epidemiological data implicate stress as a cause of seizures in both children and adults. Emerging evidence indicates that both prenatal and postnatal stress can prime the developing brain for seizures and an increase in epileptogenesis. This article reviews the cellular and molecular changes encountered during prenatal and postnatal stress, and assesses the possible link between these changes and increases in seizure occurrence and epileptogenesis in the developing hippocampus. In addititon, the priming effect of prenatal and postnatal stress for seizures and epileptogenesis is discussed. Finally, the roles of epigenetic modifications in hippocampus and HPA axis programming, early-life stress, and epilepsy are discussed VSports手机版. .

Keywords: early-life stress; epigenetic; epileptogenesis; hippocampus; hypothalamic-pituitary-adrenal axis; postnatal stress; prenatal stress; seizure. V体育安卓版.

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Figures

Figure 1
Figure 1
A conceptual diagram of how prenatal and postnatal stress act on the hippocampus and HPA axis and lead to neuropsychiatric disorders through epigenetic modifications, the so-called DOHaD as presently understood. If the early programming environment matches the later adult environment, the adults are healthy. If mismatch occurs, the adults are more likely to have diseases. Figure 1 also shows the increase seizure propensity in the context of early-life stress. See text for details. DOHaD, development origins of health and disease; HHPA, hippocampus and hypothalamic-pituitary-adrenal.
See this image and copyright information in PMC

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