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Case Reports
. 1990 Aug;40(8):1312-4.
doi: 10.1212/wnl.40.8.1312.

Immunochemical analysis of pyruvate dehydrogenase complex in 2 boys with primary lactic acidemia

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Case Reports

Immunochemical analysis of pyruvate dehydrogenase complex in 2 boys with primary lactic acidemia

A Kitano et al. Neurology. 1990 Aug.

Abstract

We examined the pyruvate dehydrogenase (PDH) complex using bio- and immunochemical methods with cultured cells derived from 2 boys with mental retardation, ataxia, and primary lactic acidemia due to partial deficiency in the PDH complex. We found a defect in dephosphorylation and the subsequent activation of the E1 alpha subunit of the enzyme VSports手机版. .

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