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. 2014 Feb;19(2):146-8.
doi: 10.1038/mp.2013.65. Epub 2013 May 21.

Microbiota is essential for social development in the mouse

L Desbonnet  1 , G Clarke  2 , F Shanahan  3 , T G Dinan  2 , J F Cryan  4
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Free PMC article

Microbiota is essential for social development in the mouse (V体育官网)

L Desbonnet et al. Mol Psychiatry. 2014 Feb.
Free PMC article
No abstract available

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Figures

Figure 1
Figure 1
Effects of germ-free (GF) rearing and germ-free bacterial colonisation (GFC) on social behaviours in male mice. In the three-chambered sociability test, GF mice failed to show the normal preference for the social chamber displayed by conventionally colonised (CC) and GFC groups during trial 2, as seen in the automated tracking images (a), the time spent in each chamber (b) and the difference between time spent in mouse and empty chambers (c). This social avoidance was reversed in GFC mice (b and c). GF and GFC mice also failed to show normal preference for social novelty displayed by CC mice during trial 3, as seen in the automated tracking images (d), the time spent in each chamber (e) and the difference between time spent in the chambers containing a novel and familiar mouse (f). In the social transmission of food preference test, GF rearing conditions altered social investigation time (g) and grooming time (h) during social interaction with demonstrator mice. There was no effect on the preference for cued food immediately after social interaction (i) and 24 h later (j). ••P<0.01, •••P<0.001 versus opposite chamber; repeated-measures analysis of variance followed by post-hoc Newman–Keuls test (n=7−13); *P<0.05, ***P<0.001 versus CC; #P<0.01, ##P<0.001 versus GF; one-way analysis of variance followed by post-hoc Newman–Keuls test (n=5–13).
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