Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site VSports app下载. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2013 Mar 28;49(6):1083-96.
doi: 10.1016/j.molcel.2013.01.010. Epub 2013 Feb 7.

Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis

Fu Yang  1 , Xi-song Huo, Sheng-xian Yuan, Ling Zhang, Wei-ping Zhou, Fang Wang, Shu-han Sun
Affiliations
Free article

"V体育平台登录" Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis

Fu Yang et al. Mol Cell. .
Free article

Erratum in (VSports手机版)

  • Mol Cell. 2013 Apr 25;50(2):303-4

Abstract (VSports)

Recently, long noncoding RNAs (lncRNAs) were found to be dysregulated in a variety of tumors. However, it remains unknown how and through what molecular mechanisms the expression of lncRNAs is controlled. In this study, we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas. We demonstrated that hypoxia-induced histone deacetylase 3 repressed lncRNA-LET by reducing the histone acetylation-mediated modulation of the lncRNA-LET promoter region. Interestingly, the downregulation of lncRNA-LET was found to be a key step in the stabilization of nuclear factor 90 protein, which leads to hypoxia-induced cancer cell invasion. Moreover, the relationship among hypoxia, histone acetylation disorder, low lncRNA-LET expression level, and metastasis was found in clinical hepatocellular carcinoma samples. These results advance our understanding of the role of lncRNA-LET as a regulator of hypoxia signaling and offer new avenues for therapeutic intervention against cancer progression. VSports手机版.

VSports app下载 - PubMed Disclaimer

"VSports手机版" Publication types

V体育ios版 - MeSH terms

V体育ios版 - Substances