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. 2012 Aug;223(2):389-93.
doi: 10.1016/j.atherosclerosis.2012.06.006. Epub 2012 Jun 17.

Epicardial adipose tissue is increased in patients with systemic lupus erythematosus

Aliza Lipson  1 , Nikolaos Alexopoulos, Gregory Randell Hartlage, Chesnal Arepalli, Annette Oeser, Aihua Bian, Tebeb Gebretsadik, Ayumi Shintani, Arthur E Stillman, C Michael Stein, Paolo Raggi
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Epicardial adipose tissue is increased in patients with systemic lupus erythematosus

V体育平台登录 - Aliza Lipson et al. Atherosclerosis. 2012 Aug.

Erratum in

  • Atherosclerosis. 2013 Jun;228(2):515

Abstract

Objective: Morbidity and mortality secondary to premature cardiovascular disease (CVD) in systemic lupus erythematosus (SLE) remain significant issues VSports手机版. The pathogenesis of CVD in SLE patients has not been fully explored. Epicardial adipose tissue (EAT) is believed to contribute to atherosclerosis development, through a paracrine and systemic inflammatory effect. We measured EAT volume in 162 SLE patients and 86 matched controls to assess the association of EAT with markers of atherosclerosis, cardiovascular risk and immunoactivation. .

Methods: Clinical and laboratory characteristics collected included anthropomorphic measures, disease activity and damage indices, blood pressure measurement, lipid profile, inflammatory indices, adipokine levels and measures of adiposity. Coronary artery calcium (CAC) and EAT volume were measured using non-contrast cardiac computed tomography. V体育安卓版.

Results: EAT volume was greater in patients with SLE [(mean ± SD) 96. 8 ± 45. 9 cm(3)] than controls (78. 2 ± 40 V体育ios版. 7 cm(3); P = 0. 001). The EAT volume was 31% larger (95% CI, 16. 5%-47. 4%) in SLE patients than controls (P < 0. 001 adjusted for age, sex, and race; after additional adjustment for waist circumference P = 0. 007). Within SLE patients, after adjusting for age, race, sex, and waist circumference, EAT volume was associated with cumulative corticosteroid dose (P = 0. 007), current corticosteroid use (P < 0. 001), HDL cholesterol (P = 0. 033), and triglycerides (P = 0. 005). EAT was significantly correlated with CAC score (P < 0. 001), but the association was attenuated after adjustment for Framingham risk score (P = 0. 051). .

Conclusion: The increased EAT volume seen in SLE patients is associated with corticosteroid use. Corticosteroids could have adverse cardiovascular effects in SLE via an increase in EAT volume, a marker of risk in the general population VSports最新版本. .

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Figures

Figure 1
Figure 1
Epicardial adipose tissue volume in SLE patients and control subjects. Data are presented as box plots, where boxes represent the interquartile range (IQR), the horizontal lines within boxes represent the median, and the horizontal lines outside the boxes represent the lower quartile minus 1.5 times the IQR or the upper quartile plus 1.5 times the IQR. * P value is from multivariable regression analysis assessing the independent association of disease status with epicardial adipose tissue volume with adjustment for age, sex, race and waist circumference.
Figure 2
Figure 2
Epicardial adipose tissue volume in SLE patients by cumulative corticosteroid dose Data are presented as box plots, where boxes represent the interquartile range (IQR), the lines within boxes represent the median, and the lines outside the boxes represent the lower quartile minus 1.5 times the IQR or the upper quartile plus 1.5 times the IQR. Q1: Cumulative corticosteroid dose between 0 and 2,732 mg Q2: Cumulative corticosteroid dose between 2,732 and 11,428 mg Q3: Cumulative corticosteroid dose between 11,428 and 27,375 mg Q4: Cumulative corticosteroid dose>= 27,375 mg * The association between corticosteroid use and EAT in patients with SLE was examined using multivariable linear regression with adjustment for age, sex, race, waist circumference and cumulative corticosteroid dose as a continuous variable (P=0.007). For visual purposes, the figure illustrates exposure to quartiles of doses of corticosteroids; the model was also significant (P= 0.005) when quartiles of cumulative corticosteroid doses were included as a categorical variable.
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References

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