Objectives: The purpose of this study was to analyze the incidence of new atrial fibrillation or flutter (AFF) in the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) database. VSports手机版.

Background: Aldosterone antagonism in heart failure might influence atrial fibrosis and remodeling and, therefore, risk of developing AFF. The development of new AFF was a pre-specified secondary endpoint in the EMPHASIS-HF study V体育安卓版. .

Methods: Patients in New York Heart Association functional class II and with ejection fraction ≤35% were eligible for EMPHASIS-HF. History of AFF at baseline was reported by investigators using the study case report form V体育ios版. New onset AFF (in those with no history of AFF at baseline) was reported using a specific endpoint form; in a sensitivity analysis we also examined the effect of eplerenone on AFF reported as an adverse event. .

Results: New onset AFF was significantly reduced by eplerenone: 25 of 911 (2. 7%) versus 40 of 883 (4. 5%) in the placebo group (hazard ratio [HR]: 0. 58, 95% confidence interval [CI]: 0. 35 to 0. 96; p = 0 VSports最新版本. 034). The reduction in the primary endpoint with eplerenone was similar among patients with and without AFF at baseline (HR: 0. 60, 95% CI: 0. 46 to 0. 79 vs. HR: 0. 70, 95% CI: 0. 57 to 0. 85, respectively; p for interaction = 0. 41). The risk of cardiovascular (CV) death or hospital admission for worsening heart failure, the primary endpoint, was not significantly different in subjects with and without AFF at baseline (both study groups combined: HR: 1. 23, 95% CI: 0. 81 to 1. 86; p = 0. 33). .

Conclusions: In patients with systolic heart failure and mild symptoms, eplerenone reduced the incidence of new onset AFF V体育平台登录. The effects of eplerenone on the reduction of major CV events were similar in patients with and without AFF at baseline. .