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Randomized Controlled Trial
. 2012 Mar;27(3):1030-5.
doi: 10.1093/ndt/gfr418. Epub 2011 Jul 25.

The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population

Jaroslav A Hubacek  1 , Ondrej Viklicky, Dana Dlouha, Silvie Bloudickova, Ruzena Kubinova, Anne Peasey, Hynek Pikhart, Vera Adamkova, Irena Brabcova, Eva Pokorna, Martin Bobak
Affiliations
Randomized Controlled Trial

VSports最新版本 - The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population

V体育平台登录 - Jaroslav A Hubacek et al. Nephrol Dial Transplant. 2012 Mar.

Abstract

Background: Genome-wide association studies identified the FTO (fat mass and obesity gene) gene as an important determinant of body weight. More recently, the FTO gene was reported to be associated with other outcomes, including major risk factors for chronic kidney disease (CKD). We investigated the role of this gene in the risk of end-stage renal disease (ESRD) caused by CKD VSports手机版. .

Methods: We conducted two large population-based case-control studies of ESRD. Study 1 compared 984 haemodialysed patients with ESRD with 2501 participants in the Czech post-MONICA study; Study 2 compared 1188 patients included in a kidney transplantation programme for ESRD with 6681 participants in the Czech HAPIEE study. The frequencies of the FTO rs17817449 single nucleotide polymorphism genotype were compared between cases and controls. V体育安卓版.

Results: The FTO rs17817449 genotype was significantly associated with CKD in both studies (P-values 0. 00004 and 0. 006, respectively). In the pooled data, the odds ratios of CKD for GG and GT, versus TT genotype, were 1. 37 (95% confidence interval 1. 20-1. 56) and 1. 17 (1 V体育ios版. 05-1. 31), respectively (P for trend <0. 0001). Among haemodialysed and kidney transplant patients, the onset of ESRD in GG homozygotes was 3. 3 (P = 0. 012) and 2. 5 (P = 0. 032) years, respectively, earlier than in TT homozygotes. .

Conclusions: These two large independent case-control studies in the general population found robust associations between the FTO rs17817449 polymorphism and the ESRD VSports最新版本. The results suggest that the morbidities associated with the FTO gene include CKD. .

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References

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