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. 1990 Nov;5(5):603-14.
doi: 10.1016/0896-6273(90)90215-2.

"V体育2025版" FGF modulates the PDGF-driven pathway of oligodendrocyte development

R D McKinnon  1 , T Matsui, M Dubois-Dalcq, S A Aaronson
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FGF modulates the PDGF-driven pathway of oligodendrocyte development

R D McKinnon et al. Neuron. 1990 Nov.

Abstract

PDGF promotes the growth of oligodendrocyte type-2 astrocyte (O-2A) glial progenitor cells and allows their timely differentiation into oligodendrocytes, the CNS myelin-forming cells. We demonstrate that basic FGF is a potent mitogen for brain O-2A progenitor cells, but blocks their differentiation into oligodendrocytes VSports手机版. Treatment with basic FGF also influences the level of expression of PDGF receptors on O-2A progenitor cells. These cells express only the alpha chain PDGF receptor, and the levels of PDGF alpha receptors decrease as the cells differentiate. In contrast, basic FGF maintains a high level of functionally responsive PDGF alpha receptors in O-2A progenitors. Thus basic FGF activates a signaling pathway that can positively regulate PDGF receptors in O-2A progenitor cells. In this way basic FGF or an FGF-like factor may modulate the production of myelin-forming cells in the CNS. .

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