Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. VSports app下载.

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

Randomized Controlled Trial
. 2011 Aug 4;365(5):395-409.
doi: 10.1056/NEJMoa1102873. Epub 2011 Jun 29.

Reduced lung-cancer mortality with low-dose computed tomographic screening

National Lung Screening Trial Research Team; Denise R Aberle, Amanda M Adams, Christine D Berg, William C Black, Jonathan D Clapp, Richard M Fagerstrom, Ilana F Gareen, Constantine Gatsonis, Pamela M Marcus, JoRean D Sicks
Collaborators
Randomized Controlled Trial

Reduced lung-cancer mortality with low-dose computed tomographic screening

"V体育2025版" National Lung Screening Trial Research Team et al. N Engl J Med. .

Abstract

Background: The aggressive and heterogeneous nature of lung cancer has thwarted efforts to reduce mortality from this cancer through the use of screening. The advent of low-dose helical computed tomography (CT) altered the landscape of lung-cancer screening, with studies indicating that low-dose CT detects many tumors at early stages. The National Lung Screening Trial (NLST) was conducted to determine whether screening with low-dose CT could reduce mortality from lung cancer. VSports手机版.

Methods: From August 2002 through April 2004, we enrolled 53,454 persons at high risk for lung cancer at 33 U. S. medical centers. Participants were randomly assigned to undergo three annual screenings with either low-dose CT (26,722 participants) or single-view posteroanterior chest radiography (26,732). Data were collected on cases of lung cancer and deaths from lung cancer that occurred through December 31, 2009 V体育安卓版. .

Results: The rate of adherence to screening was more than 90%. The rate of positive screening tests was 24. 2% with low-dose CT and 6. 9% with radiography over all three rounds. A total of 96. 4% of the positive screening results in the low-dose CT group and 94. 5% in the radiography group were false positive results. The incidence of lung cancer was 645 cases per 100,000 person-years (1060 cancers) in the low-dose CT group, as compared with 572 cases per 100,000 person-years (941 cancers) in the radiography group (rate ratio, 1. 13; 95% confidence interval [CI], 1. 03 to 1. 23). There were 247 deaths from lung cancer per 100,000 person-years in the low-dose CT group and 309 deaths per 100,000 person-years in the radiography group, representing a relative reduction in mortality from lung cancer with low-dose CT screening of 20. 0% (95% CI, 6. 8 to 26. 7; P=0. 004). The rate of death from any cause was reduced in the low-dose CT group, as compared with the radiography group, by 6. 7% (95% CI, 1. 2 to 13. 6; P=0 V体育ios版. 02). .

Conclusions: Screening with the use of low-dose CT reduces mortality from lung cancer. (Funded by the National Cancer Institute; National Lung Screening Trial ClinicalTrials VSports最新版本. gov number, NCT00047385. ). .

PubMed Disclaimer

Figures

Figure 1
Figure 1. Cumulative Numbers of Lung Cancers and of Deaths from Lung Cancer
The number of lung cancers (Panel A) includes lung cancers that were diagnosed from the date of randomization through December 31, 2009. The number of deaths from lung cancer (Panel B) includes deaths that occurred from the date of randomization through January 15, 2009.
See this image and copyright information in PMC

Comment in

References (VSports注册入口)

    1. Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008;455:1069–75. - PMC - PubMed
    1. Sanders HR, Albitar M. Somatic mutations of signaling genes in non-small-cell lung cancer. Cancer Genet Cytogenet. 2010;203:7–15. - PubMed
    1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277–300. Erratum, CA Cancer J Clin 2011;61:133-4. - PubMed
    1. Cancer of the lung and bronchus (invasive): trends in SEER incidence and U.S. mortality using the Joinpoint Regression Program, 1975-2007 with up to four Join-points, 1992-2007 with up to two Join-points, both sexes by race/ethnicity. http://seer.cancer.gov/csr/1975_2007/results_merged/sect_15_lung_bronchu....
    1. Pierce JP, Messer K, White MM, Cowling DW, Thomas DP. Prevalence of heavy smoking in California and the United States, 1965-2007. JAMA. 2011;305:1106–12. - PubMed (VSports在线直播)

"VSports注册入口" Associated data

VSports app下载 - Grants and funding