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Review
. 2011 May;34 Suppl 2(Suppl 2):S251-7.
doi: 10.2337/dc11-s227.

VSports注册入口 - Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes

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Review

Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes

Jens J Holst et al. Diabetes Care. 2011 May.
No abstract available

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Figures

Figure 1
Figure 1
Correlation between GLP-1 secretion (calculated as total GLP-1 responses to oral glucose tolerance test) in subjects with varying degrees of glucose intolerance and BMI and 2-h glucose concentrations or BMI (after logarithmic transformation). From Muscelli et al. (22).

References

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    1. Holst JJ, Gromada J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am J Physiol Endocrinol Metab 2004;287:E199–E206 - PubMed
    1. Nauck MA, Homberger E, Siegel EG, et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 1986;63:492–498 - "V体育2025版" PubMed
    1. Hare KJ, Vilsbøll T, Holst JJ, Knop FK. Inappropriate glucagon response after oral compared with isoglycemic intravenous glucose administration in patients with type 1 diabetes. Am J Physiol Endocrinol Metab 2010;298:E832–E837 - PubMed (V体育官网入口)
    1. Nauck M, Stöckmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 1986;29:46–52 - PubMed

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