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. 2011 Jul;41(7):1843-9.
doi: 10.1002/eji.201040868. Epub 2011 Jun 7.

"V体育2025版" Modulation of human T-cell functions by reactive nitrogen species

Tihana Kasic  1 , Piergiuseppe Colombo, Cristiana Soldani, Chiuhui M Wang, Elena Miranda, Massimo Roncalli, Vincenzo Bronte, Antonella Viola
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Free article

"VSports注册入口" Modulation of human T-cell functions by reactive nitrogen species

Tihana Kasic et al. Eur J Immunol. 2011 Jul.
Free article

Abstract

Previous studies have suggested that T-lymphocyte dysfunction might be attributable to nitrative stress induced by reactive nitrogen species (RNS). In this manuscript, we explored this hypothesis and provided a direct demonstration of the inhibitory effects of RNS on human T-cell signaling, activation, and migration VSports手机版. We found that short exposure of human T cells to RNS induced tyrosine phosphorylation of several proteins, including the CD3ζ chain of the TCR complex, and release of Ca2+ from intracellular stores. When the exposure to RNS was prolonged, T cells became refractory to stimulation, downregulated membrane receptors such as CD4, CD8, and chemokine receptors, and lost their ability to migrate in response to chemokines. Since substantial protein nitration, a hallmark of nitrative stress, was observed in various human cancers, intratumoral generation of RNS might represent a relevant mechanism for tumor evasion from immune surveillance. .

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