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. 2011 Mar 13;43(4):309-15.
doi: 10.1038/ng.788.

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia (V体育官网入口)

Xiao-Jing Yan  1 , Jie Xu, Zhao-Hui Gu, Chun-Ming Pan, Gang Lu, Yang Shen, Jing-Yi Shi, Yong-Mei Zhu, Lin Tang, Xiao-Wei Zhang, Wen-Xue Liang, Jian-Qing Mi, Huai-Dong Song, Ke-Qin Li, Zhu Chen, Sai-Juan Chen
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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

V体育官网入口 - Xiao-Jing Yan et al. Nat Genet. .

Abstract

Abnormal epigenetic regulation has been implicated in oncogenesis VSports手机版. We report here the identification of somatic mutations by exome sequencing in acute monocytic leukemia, the M5 subtype of acute myeloid leukemia (AML-M5). We discovered mutations in DNMT3A (encoding DNA methyltransferase 3A) in 23 of 112 (20. 5%) cases. The DNMT3A mutants showed reduced enzymatic activity or aberrant affinity to histone H3 in vitro. Notably, there were alterations of DNA methylation patterns and/or gene expression profiles (such as HOXB genes) in samples with DNMT3A mutations as compared with those without such changes. Leukemias with DNMT3A mutations constituted a group of poor prognosis with elderly disease onset and of promonocytic as well as monocytic predominance among AML-M5 individuals. Screening other leukemia subtypes showed Arg882 alterations in 13. 6% of acute myelomonocytic leukemia (AML-M4) cases. Our work suggests a contribution of aberrant DNA methyltransferase activity to the pathogenesis of acute monocytic leukemia and provides a useful new biomarker for relevant cases. .

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References

    1. Curr Opin Hematol. 2007 Mar;14(2):85-9 - PubMed
    1. J Exp Med. 2010 Feb 15;207(2):339-44 - PubMed
    1. Cancer Cell. 2003 Dec;4(6):417-8 - PubMed
    1. Am J Clin Pathol. 1981 Feb;75(2):140-8 - PubMed
    1. Hum Mol Genet. 2006 May 1;15(9):1375-85 - PubMed

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