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. 2011 Feb;18(2):120-7.
doi: 10.1038/nsmb.2000. Epub 2010 Dec 23.

Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates

Ziyang Ma  1 , Tomek Swigut, Anton Valouev, Alvaro Rada-Iglesias, Joanna Wysocka
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"V体育官网入口" Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates

V体育2025版 - Ziyang Ma et al. Nat Struct Mol Biol. 2011 Feb.

Abstract

Prdm14 is a PR-domain and zinc-finger protein whose expression is restricted to the pluripotent cells of the early embryo, embryonic stem cells (ESCs), and germ cells. Here, we show that Prdm14 safeguards mouse ESC (mESC) maintenance by preventing induction of extraembryonic endoderm (ExEn) fates VSports手机版. Conversely, Prdm14 overexpression impairs ExEn differentiation during embryoid body formation. Prdm14 occupies and represses genomic loci encoding ExEn differentiation factors, while also binding to and promoting expression of genes associated with mESC self-renewal. Prdm14-associated genomic regions substantially overlap those occupied by Nanog and Oct4, are enriched in a chromatin signature associated with distal regulatory elements and contain a unique DNA-sequence motif recognized by Prdm14 in vitro. Our work identifies a new member of the mESC transcriptional network, Prdm14, which plays a dual role as a context-dependent transcriptional repressor or activator. .

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