Introduction: Metastasis-associated protein CD24 has been identified as a new prognostic factor and stem cell marker in the human neoplasm VSports手机版. However, the importance of the CD24 in non-small cell lung carcinomas (NSCLCs) has not been elucidated well. .

Methods: We evaluated CD24 expression in 267 consecutive cases of NSCLC by immunohistochemistry using a tissue microarray technique and correlated with clinicopathologic parameters including forthcoming (seventh) new tumor node metastasis classification V体育安卓版. .

Results: CD24-high expression was demonstrated in 87 of 267 (33%) and was associated with adenocarcinoma (ADC) histology than in squamous cell carcinoma histology (64 of 165 [39%] vs. 20 of 88 [23%]; p = 0 V体育ios版. 023). Patients with CD24-high tumors tended to have a higher risk of disease progression (p < 0. 001) and cancer-related death (p = 0. 002). Multivariate analysis proved CD24-high expression as independent prognostic factors of disease progression and cancer-related death (p = 0. 002, hazard ratio = 1. 78, 95% confidence interval = 1. 23-2. 58 and p = 0. 017, hazard ratio = 1. 93, 95% confidence interval =1. 13-3. 31). CD24-high expression had a tendency to correlate with new pathologic stage (p-stage) (p = 0. 089) rather than old p-stage (p = 0. 253). Performance status and new p-stage, regardless of the tumor histology, were identified as consistent independent prognostic factors of disease progression and cancer-related death. However, age was related to a significantly shorter cancer-specific survival in ADC only. .

Conclusions: CD24 expression in NSCLC is associated with ADC histology and disease progression and cancer-related death, indicative of aggressive tumor behavior. Performance status and new p-stage, to a lesser extent, age correlated with progression-free survival and cancer-specific survival, regardless of tumor histology. VSports最新版本.