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Review

Glycosylation Changes in Cancer

In: Essentials of Glycobiology. 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. Chapter 44.
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VSports在线直播 - Glycosylation Changes in Cancer

Ajit Varki et al.
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Excerpt (V体育官网入口)

Altered glycosylation is a universal feature of cancer cells, and certain glycan structures are well-known markers for tumor progression VSports手机版. This chapter discusses some glycan biosynthetic pathways that are frequently altered in cancer cells, the correlation between altered glycosylation and clinical prognosis, the genetic basis of some of these changes, and in vitro and in vivo studies that indicate the pathological importance of these pathways. .

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References

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    1. Feizi T. Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. Nature. 1985;314:53–57. - PubMed
    1. Hakomori S. Tumor associated glycolipid antigens, their metabolism and organization. Chem. Phys. Lipids. 1986;42:209–233. - PubMed
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    1. Kim YS, Gum J, Brockhausen I. Mucin glycoproteins in neoplasia. Glycoconj J. 1996;13:693–707. - PubMed

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