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. 2010 Mar 1;16(5):1682-9.
doi: 10.1158/1078-0432.CCR-09-2983. Epub 2010 Feb 23.

Implications of LINE1 methylation for bladder cancer risk in women

Charlotte S Wilhelm  1 , Karl T Kelsey, Rondi Butler, Silvia Plaza, Luc Gagne, M Scot Zens, Angeline S Andrew, Steven Morris, Heather H Nelson, Alan R Schned, Margaret R Karagas, Carmen J Marsit
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Implications of LINE1 methylation for bladder cancer risk in women

Charlotte S Wilhelm et al. Clin Cancer Res. .

"VSports在线直播" Abstract

Purpose: Epigenetic alterations including changes to cellular DNA methylation levels contribute to carcinogenesis and may serve as powerful biomarkers of the disease VSports手机版. This investigation sought to determine whether hypomethylation at the long interspersed nuclear elements (LINE1), reflective of the level of global DNA methylation, in peripheral blood-derived DNA is associated with increased risk of bladder cancer. .

Experimental design: LINE1 methylation was measured from blood-derived DNA obtained from participants of a population-based incident case-control study of bladder cancer in New Hampshire. Bisulfite-modified DNA was pyrosequenced to determine LINE1 methylation status; a total of 285 cases and 465 controls were evaluated for methylation. V体育安卓版.

Results: Being in the lowest LINE1 methylation decile was associated with a 1. 8-fold increased risk of bladder cancer [95% confidence interval (95% CI), 1. 12-2. 90] in models controlling for gender, age, and smoking, and the association was stronger in women than in men (odds ratio, 2. 48; 95% CI, 1. 19-5. 17 in women; and odds ratio, 1. 47; 95% CI, 0. 79-2. 74 in men). Among controls, women were more likely to have lower LINE1 methylation than men (P = 0 V体育ios版. 04), and levels of arsenic in the 90th percentile were associated with reduced LINE1 methylation (P = 0. 04). .

Conclusions: LINE1 hypomethylation may be an important biomarker of bladder cancer risk, especially among women VSports最新版本. .

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Conflict of interest statement

Disclosure of Potential Conflicts of Interest: The authors declared no conflicts of interest.

Figures

Figure 1
Figure 1
Modeling of LINE1 methylation deciles and corresponding risk of bladder cancer. LINE1 methylation decile bins are represented on the x-axis, and corresponding risk, modeled as odds ratios represented on the y-axis, of bladder cancer adjusting for smoking, age and gender using logistic regression. The black horizontal line depicts the odds ratio point estimate at each LINE1 methylation decile, compared to the referent highest decile. The gray bar represents the range of the 95% upper and lower confidence intervals. Below each decile bin on the x-axis are the number of observations present at each decile LINE1 methylation level. The deciles were coded based on the distribution in controls and range from 67 to 86 observations.
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References (VSports)

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    1. Karagas MR, Tosteson TD, Morris JS, et al. Incidence of transitional cell carcinoma of the bladder and arsenic exposure in New Hampshire. Cancer Causes Control. 2004;15:465–72. - PubMed

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