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. 2009 Aug;2(4):378-83.
doi: 10.1161/CIRCEP.108.786665. Epub 2009 Apr 23.

"VSports注册入口" Familial aggregation of atrial fibrillation: a study in Danish twins

Ingrid Elisabeth Christophersen  1 , Lasse Steen Ravn, Esben Budtz-Joergensen, Axel Skytthe, Stig Haunsoe, Jesper Hastrup Svendsen, Kaare Christensen
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Familial aggregation of atrial fibrillation: a study in Danish twins

Ingrid Elisabeth Christophersen et al. Circ Arrhythm Electrophysiol. 2009 Aug.

Abstract

Background: Heritability may play a role in nonfamilial atrial fibrillation (AF) VSports手机版. We hypothesized that a monozygotic (MZ) twin whose co-twin was diagnosed with AF would have an increased risk of the disease compared with a dizygotic (DZ) twin in the same situation. .

Methods and results: A sample of 1137 same-sex twin pairs (356 MZ and 781 DZ pairs) in which one or both members were diagnosed with AF were identified in The Danish Twin Registry V体育安卓版. Concordance rates were twice as high for MZ pairs than for DZ pairs regardless of sex (22. 0% versus 11. 6%, P<0. 0001). In a Cox regression of event-free survival times, we compared the time span between occurrences of disease in MZ and DZ twins. The unaffected twin was included when his or her twin-sibling (the index twin) was diagnosed with AF. After adjustment for age at entry, MZ twins had a significantly shorter event-free survival time (hazard ratio, 2. 0; 95% CI, 1. 3 to 3. 0), thereby indicating a genetic component. Using biometric models, we estimated the heritability of AF to be 62% (55% to 68%), due to additive genetics. There were no significant differences across sexes. .

Conclusions: All the analyses of twin similarities in the present study indicate that genetic factors play a substantial role in the risk of AF for both sexes. The recurrence risk for co-twins (12% to 22%) is clinically relevant and suggests that co-twins of AF-affected twins belong to a high-risk group for AF. V体育ios版.

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Figures

Figure 1
Figure 1
Plot of cumulative incidence of atrial fibrillation as a function of zygosity for both genders analyzed together. CI=confidence interval.
See this image and copyright information in PMC

References (VSports手机版)

    1. Kannel WB, Wolf PA, Benjamin EJ, Levy D. Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates. Am J Cardiol. 1998;82:2N–9N. - V体育平台登录 - PubMed
    1. Frost L, Engholm G, Johnsen S, Moller H, Husted S. Incident stroke after discharge from the hospital with a diagnosis of atrial fibrillation. Am J Med. 2000;108:36–40. - VSports最新版本 - PubMed
    1. Frost L, Engholm G, Moller H, Husted Decrease in mortality in patients with a hospital diagnosis of atrial fibrillation in Denmark during the period 1980–1993. Eur Heart J. 1999;20:1592–1599. - PubMed
    1. Friberg J, Scharling H, Gadsboll N, Jensen GB. Sex-specific increase in the prevalence of atrial fibrillation (The Copenhagen City Heart Study) Am J Cardiol. 2003;92:1419–1423. - PubMed
    1. Brand FN, Abbott RD, Kannel WB, Wolf PA. Characteristics and prognosis of lone atrial fibrillation. 30-year follow-up in the Framingham Study. JAMA. 1985;254:3449–3453. - VSports注册入口 - PubMed

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