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. 2010 Jan 15;314(1):70-4.
doi: 10.1016/j.mce.2009.08.012. Epub 2009 Aug 22.

Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/beta-catenin signaling pathway

Jin-fang Zhang  1 , Guo Li, Chu-yan Chan, Chun-ling Meng, Marie Chia-mi Lin, Yang-chao Chen, Ming-liang He, Ping-chung Leung, Hsiang-fu Kung
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VSports手机版 - Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/beta-catenin signaling pathway

Jin-fang Zhang (V体育平台登录) et al. Mol Cell Endocrinol. .

Abstract

Herba Epimedii is one of the most commonly used Chinese herbs for treating osteoporosis. In the present study, the flavonoids of Herba Epimedii (HEF) have shown to promote the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. They were noted to enhance the mRNA expression of BMP-2, BMP-4, Runx2, beta-catenin and cyclinD1, all of which are BMP or Wnt-signaling pathway related regulators. The osteogenic effect was inhibited by the introduction of noggin and DKK-1, which is classical inhibitor of BMP and Wnt/beta-catenin signaling, respectively. These results suggest that HEF exerts promoting effect on osteogenic differentiation, which plausibly functions via the BMP and Wnt/beta-catenin signaling pathways. Considering the therapeutic efficiency and economical issues, HEF may be a potential candidate for promoting bone regeneration VSports手机版. On the other hand, osteogenic differentiation of MSCs may also be a promising and attractive tool to apply in bone repair. .

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