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Review
. 2010 Feb 28;288(2):149-55.
doi: 10.1016/j.canlet.2009.06.026. Epub 2009 Jul 22.

HPV-induced oropharyngeal cancer, immune response and response to therapy

Ha Linh Vu  1 , Andrew G Sikora, Shibo Fu, Johnny Kao
Affiliations
Review

HPV-induced oropharyngeal cancer, immune response and response to therapy

Ha Linh Vu et al. Cancer Lett. .

Abstract

Approximately 25% of head and neck squamous cell carcinoma (HNSCC) worldwide are associated with high-risk human papillomaviruses (HPV). HPV-positive HNSCCs have a more favorable outcome and greater response to therapy. While chronic HPV infection allows for the evolution of immune evasion mechanisms, viral antigens can still elicit an immune response. Moreover, a robust lymphocytic response is associated with better prognosis in a variety of tumor types including head and neck cancer. This article outlines several mechanisms whereby the observed improved response of HPV-positive tumors to radiotherapy may be related to enhancement of the immune response following radiotherapy VSports手机版. .

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