"VSports注册入口" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official VSports app下载. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2009 Jul 15;15(14):4674-9.
doi: 10.1158/1078-0432.CCR-09-0227. Epub 2009 Jul 7.

VSports注册入口 - SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer

Amanda Blackford  1 , Oscar K Serrano, Christopher L Wolfgang, Giovanni Parmigiani, Siân Jones, Xiaosong Zhang, D Williams Parsons, Jimmy Cheng-Ho Lin, Rebecca J Leary, James R Eshleman, Michael Goggins, Elizabeth M Jaffee, Christine A Iacobuzio-Donahue, Anirban Maitra, John L Cameron, Kelly Olino, Richard Schulick, Jordan Winter, Joseph M Herman, Daniel Laheru, Alison P Klein, Bert Vogelstein, Kenneth W Kinzler, Victor E Velculescu, Ralph H Hruban
Affiliations

SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer (VSports最新版本)

Amanda Blackford (V体育官网) et al. Clin Cancer Res. .

Abstract

Purpose: Recently, the majority of protein coding genes were sequenced in a collection of pancreatic cancers, providing an unprecedented opportunity to identify genetic markers of prognosis for patients with adenocarcinoma of the pancreas. VSports手机版.

Experimental design: We previously sequenced more than 750 million base pairs of DNA from 23,219 transcripts in a series of 24 adenocarcinomas of the pancreas V体育安卓版. In addition, 39 genes that were mutated in more than one of these 24 cancers were sequenced in a separate panel of 90 well-characterized adenocarcinomas of the pancreas. Of these 114 patients, 89 underwent pancreaticoduodenectomy, and the somatic mutations in these cancers were correlated with patient outcome. .

Results: When adjusted for age, lymph node status, margin status, and tumor size, SMAD4 gene inactivation was significantly associated with shorter overall survival (hazard ratio, 1. 92; 95% confidence interval, 1. 20-3. 05; P = 0. 006). Patients with SMAD4 gene inactivation survived a median of 11. 5 months, compared with 14 V体育ios版. 2 months for patients without SMAD4 inactivation. By contrast, mutations in CDKN2A or TP53 or the presence of multiple (> or =4) mutations or homozygous deletions among the 39 most frequently mutated genes were not associated with survival. .

Conclusions: SMAD4 gene inactivation is associated with poorer prognosis in patients with surgically resected adenocarcinoma of the pancreas. VSports最新版本.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Kaplan Meier curves of survival probability by patients with and without mutation or deletion in the SMAD4 gene.
Figure 2
Figure 2
Kaplan Meier curves of survival probability by patients with and without mutation or deletion in the TGFβR2 gene.
Figure 3
Figure 3
Kaplan Meier curves of survival probability by patients with and without mutation or deletion in the TP53 gene.
Figure 4
Figure 4
Kaplan Meier curves of survival probability by patients with < 4 mutations or homozygous deletions and with ≥4 mutations or homozygous deletions.
See this image and copyright information in PMC

References

    1. Jemal A, Siegel R, Ward E, et al. Cancer statistics. CA Cancer J Clin. 2008;58:71–96. - "V体育平台登录" PubMed
    1. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer. 2001;94:153–6. - PubMed
    1. Hruban RH, Pitman MB, Klimstra DS. Fourth Series, Fascicle. 6. Washington, DC: American Registry of Pathology and Armed Forces Institute of Pathology; 2007. Tumors of the pancreas. Atlas of tumor pathology.
    1. Sohn TA, Yeo CJ, Lillemoe KD, et al. Resected adenocarcinoma of the pancreas - 616 patients: results, outcome, and prognostic indications. J Gastroenterol Surg. 2000;4:567–79. - PubMed
    1. Yeo CJ, Abrams RA, Grochow LB, et al. Pancreaticoduodenectomy for pancreatic adenocarcinoma: postoperative adjuvant chemoradiation improves survival. A prospective, single-institution experience. Ann Surg. 1997;225:621–33. - PMC - PubMed

Publication types

MeSH terms

Substances