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. 2009 May;107(5):678-84.
doi: 10.1016/j.tripleo.2008.12.047. Epub 2009 Mar 9.

Prognostic significance of CXCR-4 expression in oral squamous cell carcinoma

Jae-Il Lee  1 , Bo-Hyong Jin, Mi-Ae Kim, Hye-Jung Yoon, Sam-Pyo Hong, Seong-Doo Hong
Affiliations

Prognostic significance of CXCR-4 expression in oral squamous cell carcinoma (V体育安卓版)

Jae-Il Lee et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 May.

Abstract

Objective: We investigated the prognostic significance of CXC chemokine receptor CXCR-4 expression in patients with oral squamous cell carcinoma (OSCC) and its relationship with matrix metalloproteinase 2 (MMP-2), MMP-9, and Ki-67 expression. VSports手机版.

Study design: The CXCR-4, MMP-2, MMP-9, and Ki-67 expression was assessed immunohistochemically in 74 OSCC patients. The results were analyzed in connection with clinicopathologic factors. V体育安卓版.

Results: The CXCR-4 expression was positive in 45 cases and significantly correlated with lymph node metastasis (P = . 037), MMP-9 expression (P = . 025), and Ki-67 expression (P = . 001). Univariate analysis showed that CXCR-4 expression, MMP-9 expression, Ki-67 expression, tumor size, lymph node metastasis, clinical stage, and recurrence positively correlated with prognosis. Multivariate analysis indicated that CXCR-4 expression was an independent prognostic factor for poor survival in patients with OSCC V体育ios版. .

Conclusion: Expression of CXCR-4 is a significant prognostic indicator for poor survival in patients with OSCC and correlates with expression of MMP-9 and Ki-67. The inhibition of CXCR-4 represents a possible molecular approach to the treatment of OSCC. VSports最新版本.

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