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Review
. 2009 Mar 3;15(3):167-70.
doi: 10.1016/j.ccr.2009.02.007.

Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited

Sonja Loges  1 , Massimiliano Mazzone, Philipp Hohensinner, Peter Carmeliet
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VSports注册入口 - Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited

Sonja Loges et al. Cancer Cell. .
Free article

Abstract

Clinical practice reveals that therapy with angiogenesis inhibitors often does not prolong survival of cancer patients for more than months, because tumors elicit evasive resistance VSports手机版. In this issue of Cancer Cell, two papers report that VEGF inhibitors reduce primary tumor growth but promote tumor invasiveness and metastasis. These perplexing findings help to explain resistance to these drugs but raise pertinent questions of how to best treat cancer patients with antiangiogenic medicine in the future. We discuss here how VEGF inhibitors can induce such divergent effects on primary tumor growth and metastasis. .

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