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. 2009 Jan;37(Database issue):D98-104.
doi: 10.1093/nar/gkn714. Epub 2008 Oct 15.

VSports注册入口 - miR2Disease: a manually curated database for microRNA deregulation in human disease

Qinghua Jiang  1 , Yadong Wang, Yangyang Hao, Liran Juan, Mingxiang Teng, Xinjun Zhang, Meimei Li, Guohua Wang, Yunlong Liu
Affiliations

miR2Disease: a manually curated database for microRNA deregulation in human disease

"VSports注册入口" Qinghua Jiang et al. Nucleic Acids Res. 2009 Jan.

"VSports最新版本" Abstract

'miR2Disease', a manually curated database, aims at providing a comprehensive resource of microRNA deregulation in various human diseases. The current version of miR2Disease documents 1939 curated relationships between 299 human microRNAs and 94 human diseases by reviewing more than 600 published papers VSports手机版. Around one-seventh of the microRNA-disease relationships represent the pathogenic roles of deregulated microRNA in human disease. Each entry in the miR2Disease contains detailed information on a microRNA-disease relationship, including a microRNA ID, the disease name, a brief description of the microRNA-disease relationship, an expression pattern of the microRNA, the detection method for microRNA expression, experimentally verified target gene(s) of the microRNA and a literature reference. miR2Disease provides a user-friendly interface for a convenient retrieval of each entry by microRNA ID, disease name, or target gene. In addition, miR2Disease offers a submission page that allows researchers to submit established microRNA-disease relationships that are not documented. Once approved by the submission review committee, the submitted records will be included in the database. miR2Disease is freely available at http://www. miR2Disease. org. .

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Figures

Figure 1.
Figure 1.
A schematic workflow of miR2Disease.
Figure 2.
Figure 2.
Distribution of diseases and deregulated microRNAs documented in miR2Disease database. (A) Histogram of the number of diseases associated with individual microRNA. (B) Histogram of the number of deregulated microRNAs associated with individual disease.
Figure 3.
Figure 3.
A bipartite network demonstrating the causal relationship between deregulated microRNAs and variety of cancers. Circles and rectangles correspond to microRNAs and diseases, respectively. An edge is placed between a microRNA and a disease if the microRNA deregulation plays causative role in pathogenesis of the disease. Solid circles indicate master microRNAs that potentially cause no less than five types of cancers.
See this image and copyright information in PMC

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