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. 2008 Nov;71(11):1911-4.
doi: 10.1021/np800233q. Epub 2008 Oct 15.

"V体育ios版" Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo

Hao Liang  1 , Baitang Lai, Qipeng Yuan
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V体育2025版 - Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo

Hao Liang et al. J Nat Prod. 2008 Nov.

Abstract

Sulforaphane (1), a glucosinolate-derived isothiocyanate found in the cruciferous vegetable broccoli, is considered an anticarcinogenic component. In the present study, the proliferation and apoptosis induction in human lung adenocarcinoma LTEP-A2 cells by 1 was investigated VSports手机版. Compound 1 caused G(2)/M-phase arrest (p < 0. 05) and increase of apoptotic cell fraction (p < 0. 05) in a time- and dose-dependent manner. Intraperitoneal injection of 1 significantly inhibited growth of LTEP-A2 xenografts in nude mice, and 9 days after tumor cell implantation with 100 mg/kg intraperitoneal injection of 1, the average tumor weights in 1-treated mice was >70% lower than that of the control mice. .

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