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. 2008 Nov 14;376(2):404-8.
doi: 10.1016/j.bbrc.2008.09.001. Epub 2008 Sep 16.

Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells

Byung-Hee Chung  1 , Jong-Dai Kim, Chun-Ki Kim, Jung Hwan Kim, Moo-Ho Won, Han-Soo Lee, Mi-Sook Dong, Kwon-Soo Ha, Young-Geun Kwon, Young-Myeong Kim
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VSports手机版 - Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells

Byung-Hee Chung et al. Biochem Biophys Res Commun. .

Erratum in

  • Biochem Biophys Res Commun. 2009 Jun 12;383(4):522. Kim, Jung Huan [corrected to Kim, Jung Hwan]

Abstract

We investigated the molecular effect and signal pathway of icariin, a major flavonoid of Epimedium koreanum Nakai, on angiogenesis. Icariin stimulated in vitro endothelial cell proliferation, migration, and tubulogenesis, which are typical phenomena of angiogenesis, as well as increased in vivo angiogenesis. Icariin activated the angiogenic signal modulators, ERK, phosphatidylinositol 3-kinase (PI3K), Akt, and endothelial nitric oxide synthase (eNOS), and increased NO production, without affecting VEGF expression, indicating that icariin may directly stimulate angiogenesis VSports手机版. Icariin-induced ERK activation and angiogenic events were significantly inhibited by the MEK inhibitor PD98059, without affecting Akt and eNOS phosphorylation. The PI3K inhibitor Wortmannin suppressed icariin-mediated angiogenesis and Akt and eNOS activation without affecting ERK phosphorylation. Moreover, the NOS inhibitor NMA partially reduced the angiogenic activity of icariin. These results suggest that icariin stimulated angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways and may be a useful drug for angiogenic therapy. .

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