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. 2008 Sep 18;268(2):314-24.
doi: 10.1016/j.canlet.2008.04.017. Epub 2008 May 27.

"VSports app下载" Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

Chih-Chen Hong  1 , Jong-Ding Lay, Jhy-Shrian Huang, Ann-Lii Cheng, Jih-Luh Tang, Ming-Tseh Lin, Gi-Ming Lai, Shuang-En Chuang
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VSports注册入口 - Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

Chih-Chen Hong et al. Cancer Lett. .

Abstract

By using a novel profiling analysis of protein tyrosine kinases differentially expressed in the sensitive and refractory leukemia from the same patients we found that AXL was upregulated in drug-resistant leukemia. Furthermore, AXL could be induced by chemotherapy drugs in the acute myeloid leukemia U937 cells and this induction was dependent on the CCWGG methylation status of the AXL promoter. In U937 cells ectopically overexpressing AXL, addition of exogenous Gas6 induced AXL phosphorylation and activation of the Akt and ERK1/2 survival pathways VSports手机版. The Gas6-AXL activation pathway of drug resistance was associated with increased expression of Bcl-2 and Twist. These results show that upregulation of AXL by chemotherapy might induce drug resistance in acute myeloid leukemia in the presence of Gas6 stimulation. .

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