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Review
. 2006 Apr-Jun;1(2):63-6.
doi: 10.4161/epi.1.2.2767. Epub 2006 Apr 5.

On the enzymatic properties of Dnmt1: specificity, processivity, mechanism of linear diffusion and allosteric regulation of the enzyme

Albert Jeltsch  1
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Free article
Review

On the enzymatic properties of Dnmt1: specificity, processivity, mechanism of linear diffusion and allosteric regulation of the enzyme

Albert Jeltsch. Epigenetics. 2006 Apr-Jun.
Free article

Abstract

In this short review the enzymatic properties of Dnmt1 are summarized. Studies on the specificity of Dnmt1 have shown that it has 30-40 fold preference for hemimethylated target sites. It methylates hemimethylated DNA in a processive reaction, moving on the DNA in a random walk VSports手机版. Binding of DNA to allosteric site(s) in the N-terminal part of the enzyme can lead to stimulation and inhibition of its catalytic activity depending on the nature of the substrate and effector. .

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