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Review
. 2007 Dec;17(6):422-9.
doi: 10.1016/j.semcancer.2007.06.010. Epub 2007 Jun 28.

HLA-G expression in malignant melanoma (VSports)

Vera Rebmann  1 , Stefan Wagner, Hans Grosse-Wilde
Affiliations
Review

HLA-G expression in malignant melanoma

Vera Rebmann et al. Semin Cancer Biol. 2007 Dec.

Abstract

Both, the expression of HLA-G (a non-classical HLA class I molecule) and the loss of classical HLA class I molecules enable tumor cells to evade from immunosurveillance of the host VSports手机版. Whereas HLA-G down-modulates the immune functions of all cells participating in the immune defence mechanisms, defects on HLA class I expression result in the resistance of tumor cells to cytotoxic T lymphocytes attacks. This contribution reviews the HLA-G expression pattern in malignant melanoma lesions, its correlation to the loss of classical HLA class I antigens, and new aspects of HLA-G regulation. .

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