Background: Only a few types of cancer are recognised as being directly related to immune deficiency in people with HIV/AIDS. Large population-based studies in transplant recipients have shown that a wider range of cancers could be associated with immune deficiency VSports手机版. Our aim was to compare cancer incidence in population-based cohort studies of people with HIV/AIDS and people immunosuppressed after solid organ transplantation. .

Methods: Two investigators independently identified eligible studies through searches of PubMed and reference lists. Random-effects meta-analyses of log standardised incidence ratios (SIRs) were calculated by type of cancer for both immune deficient populations V体育安卓版. .

Findings: Seven studies of people with HIV/AIDS (n=444,172) and five of transplant recipients (n=31 977) were included. For 20 of the 28 types of cancer examined, there was a significantly increased incidence in both populations. Most of these were cancers with a known infectious cause, including all three types of AIDS-defining cancer, all HPV-related cancers, as well as Hodgkin's lymphoma (HIV/AIDS meta-analysis SIR 11. 03, 95% CI 8. 43-14. 4; transplant 3. 89, 2. 42-6. 26), liver cancer (HIV/AIDS 5. 22, 3. 32-8. 20; transplant 2 V体育ios版. 13, 1. 16-3. 91), and stomach cancer (HIV/AIDS 1. 90, 1. 53-2. 36; transplant 2. 04, 1. 49-2. 79). Most common epithelial cancers did not occur at increased rates. .

Interpretation: The similarity of the pattern of increased risk of cancer in the two populations suggests that it is immune deficiency, rather than other risk factors for cancer, that is responsible for the increased risk VSports最新版本. Infection-related cancer will probably become an increasingly important complication of long-term HIV infection. .