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. 2007 Mar;9(3):255-67.
doi: 10.1038/ncb1542. Epub 2007 Feb 11.

Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells

Arianna Dellavalle  1 , Maurilio Sampaolesi, Rossana Tonlorenzi, Enrico Tagliafico, Benedetto Sacchetti, Laura Perani, Anna Innocenzi, Beatriz G Galvez, Graziella Messina, Roberta Morosetti, Sheng Li, Marzia Belicchi, Giuseppe Peretti, Jeffrey S Chamberlain, Woodring E Wright, Yvan Torrente, Stefano Ferrari, Paolo Bianco, Giulio Cossu
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"V体育2025版" Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells

"VSports最新版本" Arianna Dellavalle et al. Nat Cell Biol. 2007 Mar.
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Abstract

Cells derived from blood vessels of human skeletal muscle can regenerate skeletal muscle, similarly to embryonic mesoangioblasts VSports手机版. However, adult cells do not express endothelial markers, but instead express markers of pericytes, such as NG2 proteoglycan and alkaline phosphatase (ALP), and can be prospectively isolated from freshly dissociated ALP(+) cells. Unlike canonical myogenic precursors (satellite cells), pericyte-derived cells express myogenic markers only in differentiated myotubes, which they form spontaneously with high efficiency. When transplanted into severe combined immune deficient-X-linked, mouse muscular dystrophy (scid-mdx) mice, pericyte-derived cells colonize host muscle and generate numerous fibres expressing human dystrophin. Similar cells isolated from Duchenne patients, and engineered to express human mini-dystrophin, also give rise to many dystrophin-positive fibres in vivo. These data show that myogenic precursors, distinct from satellite cells, are associated with microvascular walls in the human skeletal muscle, may represent a correlate of embryonic 'mesoangioblasts' present after birth and may be a promising candidate for future cell-therapy protocols in patients. .

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