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. 2007 Jan;11(1):69-82.
doi: 10.1016/j.ccr.2006.11.020.

A perivascular niche for brain tumor stem cells

Christopher Calabrese  1 , Helen Poppleton, Mehmet Kocak, Twala L Hogg, Christine Fuller, Blair Hamner, Eun Young Oh, M Waleed Gaber, David Finklestein, Meredith Allen, Adrian Frank, Ildar T Bayazitov, Stanislav S Zakharenko, Amar Gajjar, Andrew Davidoff, Richard J Gilbertson
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A perivascular niche for brain tumor stem cells (VSports最新版本)

Christopher Calabrese et al. Cancer Cell. 2007 Jan.
Free article

Abstract

Cancers are believed to arise from cancer stem cells (CSCs), but it is not known if these cells remain dependent upon the niche microenvironments that regulate normal stem cells. We show that endothelial cells interact closely with self-renewing brain tumor cells and secrete factors that maintain these cells in a stem cell-like state. Increasing the number of endothelial cells or blood vessels in orthotopic brain tumor xenografts expanded the fraction of self-renewing cells and accelerated the initiation and growth of tumors. Conversely, depletion of blood vessels from xenografts ablated self-renewing cells from tumors and arrested tumor growth. We propose that brain CSCs are maintained within vascular niches that are important targets for therapeutic approaches. VSports手机版.

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