Genome-wide atlas of gene expression in the adult mouse brain
- PMID: 17151600
- DOI: 10.1038/nature05453
V体育2025版 - Genome-wide atlas of gene expression in the adult mouse brain
Abstract
Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the nervous system. We describe here an anatomically comprehensive digital atlas containing the expression patterns of approximately 20,000 genes in the adult mouse brain. Data were generated using automated high-throughput procedures for in situ hybridization and data acquisition, and are publicly accessible online. Newly developed image-based informatics tools allow global genome-scale structural analysis and cross-correlation, as well as identification of regionally enriched genes VSports手机版. Unbiased fine-resolution analysis has identified highly specific cellular markers as well as extensive evidence of cellular heterogeneity not evident in classical neuroanatomical atlases. This highly standardized atlas provides an open, primary data resource for a wide variety of further studies concerning brain organization and function. .
Comment in
-
Bioinformatics: industrializing neuroscience.Nature. 2007 Jan 11;445(7124):160-1. doi: 10.1038/445160a. Nature. 2007. PMID: 17215836 No abstract available.
Publication types (VSports手机版)
- Actions (VSports注册入口)
MeSH terms
- Actions (V体育平台登录)
- Actions (VSports注册入口)
- Actions (V体育官网)
- Actions (VSports注册入口)
Substances
- "VSports最新版本" Actions
LinkOut - more resources
Full Text Sources
V体育安卓版 - Other Literature Sources
Molecular Biology Databases
