Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2007 Feb 8;26(6):851-8.
doi: 10.1038/sj.onc.1209846. Epub 2006 Jul 31.

"VSports app下载" A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas

R Lin  1 , S Maeda, C Liu, M Karin, T S Edgington
Affiliations

"VSports注册入口" A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas

R Lin et al. Oncogene. .

Abstract

Tumor markers can facilitate understanding molecular cell biology of neoplasia and provide potential targets for the diagnosis and insight for intervention. We here identify a novel murine gene, hepcarcin (hcn), encoding a 7-kb mRNA-like transcript VSports手机版. The gene appears to be the murine ortholog of the human alpha gene, that is, MALAT-1. The gene and homologs lack credible open reading frames, consistent with a highly conserved large noncoding RNA (ncRNA). In all nodules of procarcinogen-induced murine hepatocellular carcinomas (HCCs) and human HCCs, expression was markedly elevated compared to the uninvolved liver. Quantitative analyses indicated a 6-7-fold increased RNA level in HCCs versus uninvolved liver, advancing this as a molecule of interest. This ncRNA was overexpressed in all five non-hepatic human carcinomas analysed, consistent with a potential marker for neoplastic cells and potential participant in the molecular cell biology of neoplasia. .

PubMed Disclaimer

Publication types

MeSH terms

Associated data

V体育平台登录 - LinkOut - more resources