Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

Review
. 2006 Jun;6(4):313-23.
doi: 10.2174/156800906777441771.

VSports注册入口 - NOTCH signaling as a novel cancer therapeutic target

L Miele  1 , H Miao, B J Nickoloff
Affiliations
Review

"V体育平台登录" NOTCH signaling as a novel cancer therapeutic target

L Miele et al. Curr Cancer Drug Targets. 2006 Jun.

"V体育安卓版" Abstract

NOTCH-ligand interaction is a highly conserved mechanism that regulates specific cell fate decision during development VSports手机版. In addition to its functions in developmental and cell maturation processes, studies indicate that NOTCH activation plays a role in the onset and progression of many human malignancies. The prevailing new strategy for rationally targeted cancer treatment is aimed at the development of target-selective "smart" drugs on the basis of characterized mechanisms of action. The connection between NOTCH signaling and tumorigenesis suggests that NOTCH may be such a target candidate. Gamma-secretase is a large membrane-integral multisubunit protease complex, which is essential for NOTCH receptor activation. Inhibitors of this enzyme are being developed for Alzheimer's disease, due to its role in cleaving beta-amyloid precursor in the brain. Recently, Gamma-secretase inhibitors (GSIs), as well as various biopharmaceutical or genetic NOTCH signaling inhibitors have been suggested as potential novel cancer therapeutic strategies. This review summarizes the evidence linking NOTCH signaling to several types of cancer, as well as the possible therapeutic indications of NOTCH inhibitors and the challenges facing their clinical development. .

PubMed Disclaimer

"V体育安卓版" Publication types

"V体育安卓版" MeSH terms

LinkOut - more resources