Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official VSports app下载. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2005 Aug 12;309(5737):1074-8.
doi: 10.1126/science.1110955.

TAZ, a transcriptional modulator of mesenchymal stem cell differentiation

Jeong-Ho Hong  1 , Eun Sook Hwang, Michael T McManus, Adam Amsterdam, Yu Tian, Ralitsa Kalmukova, Elisabetta Mueller, Thomas Benjamin, Bruce M Spiegelman, Phillip A Sharp, Nancy Hopkins, Michael B Yaffe
Affiliations

VSports - TAZ, a transcriptional modulator of mesenchymal stem cell differentiation

Jeong-Ho Hong et al. Science. .

"V体育ios版" Abstract

Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into several distinct lineages. Two key transcription factors, Runx2 and peroxisome proliferator-activated receptor gamma (PPARgamma), drive MSCs to differentiate into either osteoblasts or adipocytes, respectively. How these two transcription factors are regulated in order to specify these alternate cell fates remains a pivotal question. Here we report that a 14-3-3-binding protein, TAZ (transcriptional coactivator with PDZ-binding motif), coactivates Runx2-dependent gene transcription while repressing PPARgamma-dependent gene transcription. By modulating TAZ expression in model cell lines, mouse embryonic fibroblasts, and primary MSCs in culture and in zebrafish in vivo, we observed alterations in osteogenic versus adipogenic potential. These results indicate that TAZ functions as a molecular rheostat that modulates MSC differentiation. VSports手机版.

PubMed Disclaimer

Publication types

"V体育平台登录" MeSH terms

Substances