Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)
- PMID: 15652422
- DOI: 10.1016/j.jneuroim.2004.10.009
Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)
Abstract
Sporadic amyotrophic lateral sclerosis (sALS) is a progressive neuroinflammatory disease of spinal cord motor neurons of unclear etiology VSports手机版. Blood from 38 patients with sALS, 28 aged-match controls, and 25 Alzheimer's disease (AD) patients were evaluated and activated monocyte/macrophages were observed in all patients with sALS and AD; the degree of activation was directly related to the rate of sALS disease progression. Other parameters of T-cell activation and immune globulin levels showed similar disease associated changes. These data are consistent with a disease model previously suggested for AD, wherein systemic immunologic activation plays an active role in sALS. .
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