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. 1992 Apr 16;356(6370):618-22.
doi: 10.1038/356618a0.

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin

J H Hartwig  1 , M Thelen, A Rosen, P A Janmey, A C Nairn, A Aderem
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MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin

J H Hartwig et al. Nature. .

Abstract (V体育官网)

AGONISTS that stimulate protein kinase C (PKC) induce profound changes in cell morphology correlating with the reorganization of submembranous actin, but no direct connection between PKC and actin assembly has been identified. The myristoylated, alanine-rich C kinase substrate (MARCKS) binds calmodulin and is a predominant, specific substrate of PKC which is phosphorylated during macrophage and neutrophil activation , growth factor-dependent mitogenesis and neurosecretion; it is redistributed from plasma membrane to cytoplasm when phosphorylated and is involved in leukocyte motility. Here we report that MARCKS is a filamentous (F) actin crosslinking protein, with activity that is inhibited by PKC-mediated phosphorylation and by binding to calcium-calmodulin. MARCKS may be a regulated crossbridge between actin and the plasma membrane, and modulation of the actin crosslinking activity of the MARCKS protein by calmodulin and phosphorylation represents a potential convergence of the calcium-calmodulin and PKC signal transduction pathways in the regulation of the actin cytoskeleton. VSports手机版.

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